The standard contains many difficult-to-detect variants, including structural variants and INDELS ranging from 1 bp to 30 bp. Detection of individual variants can depend on what aligner and alignment setting the customer is using. These hard to detect variants are for experienced customers using their pipeline. So just having an understanding of it. SNVs and small INDELs (e.g. 5 bp or smaller) are more straightforward for customers to detect.