Functional Cell-Based Assays

Off-the-shelf or custom assay development to characterize your antibodies

Overview
BENEFITS

Well Characterized Antibodies To Get From Hit to Lead

Biological activity and determining the MoA for your lead antibodies can be the final step before moving into in vivo testing. 

Twist Biopharma Solutions’ scientific experts use off-the-shelf or can develop custom cell-based assays to put your biochemical and biophysical data in context. Along with our high-throughput antibody expression and robust portfolio of characterization services and exceptional track record, we can help you make an informed decision about which leads will give you the greatest chance of preclinical success.

Uncover Hits Against Virtually Any Target

Flexible Testing for Your Needs

Our antibody experts offer various common off-the-shelf signaling assays focused on GPCRs and pathways that are important for immunology and immuno-oncoloy applications, including:

GPCR SIGNALLING

cAMP reporter assay and β-arrestin reporter assay

INTERNALIZATION

NFKB LUCIFERASE ASSAY

NFAT LUSIFERASE ASSAY

AP1 LUCIFERASE ASSAY

WNT LUCIFERASE ASSAY

TCF/LEF LUCIFERASE ASSAY

Specialized Immune Assays

We also conduct specialized immune assays for T-cell, B-cell, dendritic cell, natural killer cell, and
macrophage: Our functional assays team can also develop a custom assay that fits your program’s
needs.

CYTOKUNE RELEASE

CYTOTOXICITY

ACTIVATION

PHAGOCYTOSIS

PROLIFERATION

Complementary Services for Therapeutic Antibody Development

Antibody production, affinity assessment, epitope binning, and developability assessment play crucial roles alongside the functional testing of a candidate antibody. Twist offers these services as an integrated end-to-end discovery workflow or as a standalone service, providing you with the format that fits your needs best. Together, these services create a comprehensive picture of an antibody's therapeutic potential, guiding you toward the most promising candidates for preclinical and clinical studies.