Next-Generation Sequencing

Achieve superior enrichment efficiency with Twist Bioscience NGS Target Enrichment Solutions. Targeted sequencing takes a step forward with an optimized enrichment workflow and easy customization of panel content

Sample to sequencer in a single day

High fidelity dsDNA probes verified by NGS QC

Rapid Customization

From small panels to >1 million probes per pool

Maximized Sequencing Efficiency & Exceptional Coverage Uniformity

Increase coverage depth or run more samples on the same budget.

Raise Confidence in Variant Detection

Leave no molecule behind, capture every molecule.

Increased Depth While Reducing Overall Sequencing

Our probes enable improved coverage of intended targets when compared to the competition. Improved uniformity increases the percentage of bases covered at the desired depth and reduces the amount of over sequencing.

NGS Cumulative Coverage
Increasing depth while reducing overall sequencing

Higher Confidence in Variant Detection

Uniformity describes the read distribution along target regions of the genome. Uniform coverage reduces the amount of sequencing required to reach a sufficient depth of coverage for all regions of interest. Achieving the sequencing requirement for your application equates to higher confidence in variant detection.

Learn more about NGS

 

Testimonials

“
Having flexible and cost-effective panels has allowed us to do more samples and go deeper and deeper” to detect those low, low fraction variants
Brendan Blumenstiel
Broad Institute of MIT and Harvard
“
I heard a rumour of “incredible uniformity” regarding Twist's Target Enrichment tools. We decided to try the Twist Exome to form our own opinions. The rumor was true! Not only was uniformity incredible, but coverage was, as well. Now we use a Twist Custom Panel tailored to the specific requirements of our patients.
Simon von Ameln, PhD
ÜBAG Dres. Habets / Keller / Groschek / Danaei – Aachen, Germany
“
Twist Custom Panels allowed us to focus on important, medically relevant genes instead of the whole genome. The panel was concise, with a simple protocol, and the cost reasonable with very good candidate variants already curated by the literature.
Renata Pelligrino, PhD
Children’s Hospital of Philadelphia

More NGS Resources

Twist Target Enrichment Standard Hybridization v1 Protocol
Protocol NGS
A comprehensive protocol for the enrichment of genomic DNA libraries with a 16-hour hybridization in a two day workflow
The Utility of Twist Respiratory Viral Controls for SARS-CoV-2 and Multiplexed Pathogen Detection
Technical Note Synthetic Controls
Diverse respiratory virus controls for the accurate delineation between infectious agents with overlapping symptoms
Custom enrichment for RNA sequencing of liquid biopsies
Webinar NGS
Believe in Better: Leading the Way in Target Enrichment

MORE RESOURCES

Quick Links