AI/ML-Powered Affinity Maturation

Rapid and Scalable Methods for Improving Antibody Affinity

Overview
BENEFITS

Optimize Binding Strength, No Libraries Required

Improving the affinity of your leads is necessary for unlocking their full potential and advancing to preclinical studies.   Twist Biopharma Solutions’ next-generation artificial intelligence (AI) platform can direct the affinity maturation of antibody leads without the need for custom library generation. Along with our in silico humanization and a suite of Twist Antibody Optimization (TAO) platforms, our affinity maturation capabilities can reduce the typical workflows from months to weeks.

Rapid and Scalable Affirnity Enhancement

Rapid and Scalable Affinity Enhancement

Twist has developed an AI/ML-powered affinity maturation platform that circumvents the need for custom library construction and phage display-based screening. Our automated platform easily assesses a wide range of sequence space, quickly providing a diverse panel of antibodies for affinity testing.

A Workflow Designed for Speed

We rapidly generate up to 96 variants while maintaining position-based diversity in the CDRs. We provide a motif-based liability report to identify potential downstream developability issues. Twist will provide a visual map of proposed variants and matrixed HC/LC DNA files ensures all potential candidates are evaluated.

Integrated Capabilities to Reduce Your Time to Market

Twist’s affinity maturation pipeline seamlessly integrates with our comprehensive suite of complementary express offerings for a more holistic solution to antibody optimization. By incorporating our AI-driven Affinity Maturation into your program, we can facilitate a lower-cost, streamlined path to the clinic.