Genes
Oligo Pools
NGS
Variant Libraries
Synthetic Controls
Antibody Discovery
IVDR Solutions
The mouse is an extremely important model system for studying genetic variation, tumor mutations, and phenotypic outcomes as well as the therapeutic effect of pharmaceutical agents. As genetic variant databases are continuously updated, the Twist Mouse Exome panel is thoughtfully designed and built from the most current databases. When combined with Twist’s expanding portfolio of library preparation and enrichment reagents, the complete toolset allows researchers to achieve industry-leading coverage across target regions while optimizing sequencing cost and sample throughput.
- OVERVIEW
- DATA
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KEY BENEFITS
Up to date content
- Based on mouse genome assembly mm10
- 37.7 Mb comprehensive coverage of major gene annotation databases
Unparalleled performance
- 95% of targeted regions covered at 20x with only 5Gb sequencing
- High complexity libraries for high sensitivity variant calling
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Revolutionizing Target Enrichment
With 5-Gb sequencing, the narrow variance and mode of the coverage distribution (left) reduces both the number of bases found below the targeted level of coverage (right) and the over- and under-sequencing from the typically skewed coverage associated with poorer uniformity. This is aided by the balanced capture profile across a much wider range of target %GC content.
Enabling genetic research of this important model organism
Picard metrics of the Twist Mouse Exome Kit with two strains of mouse. Data obtained with 5 Gb (135x) sequencing.
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