The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.
- OVERVIEW
- DATA
- CUSTOMIZATION
- ORDERING & SPECS
- RESOURCES
KEY BENEFITS
Exceptional performance
- High fidelity double stranded DNA probes with optimized performance
- NGS QC of all probes
- Uniform enrichment of target regions
Greater flexibility
- Customization tools allow the rapid and scalable implementation of custom exomes
- Modular kit structure enables workflow flexibility for easy integration into existing protocols
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Maximized sequencing efficiency
- Increased depth per sample or more samples per run
- Lower sequencing costs
EXOME DEFINITION
33 Mb CCDS coverage
99% of ClinVar variants covered
99.3% of targeted regions covered at 20x with 5.3 Gb
Uncompromised Performance
Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.
Run more samples with the same budget
The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth.
Efficient Read Usage
Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate
Customization of Core Exome Kit Content and Components
The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.
Additional content with high enrichment uniformity
Increased coverage of specific genes covered by Core Exome
Optimization of spike-in ratio by customer
Product SKUs
102025
Twist Human Core Exome, 2 Reactions, Kit
102026
Twist Human Core Exome, 12 Reactions, Kit
102027
Twist Human Core Exome, 96 Reactions, Kit
SPECIFICATIONS
Workflow Step
Target Enrichment
Format
dsDNA
Panel size
33 Mb
Content
Human protein coding genes
Design Databases
CCDS
Storage
Store at -5 to -30°C
The Twist Human Core Exome are for research use only, and subject to additional use restrictions as set forth in Twist’s SupplyTerms and Conditions
Twist Human Core Exome Panel Product Sheet.
A Cost-Effective Pan-Genome-Based Platform for Genotype Imputation, QTL Mapping, and Breeding Support
Evaluating the Efficiency of the Twist Human Core Exome Kit for Target Sequencing
Core Exome .bed Files
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
