Custom Library Generation (TAO)

Strengthen Your Most Promising Antibody Leads

OVERVIEW
BENEFITS
TECHNICAL RESOURCES

Precision DNA Synthesis Paired with Multi-Parameter Optimization

The antibody optimization process requires designing and testing many combinations of antibody variants to narrow in on a developable, functional, optimal candidate.

Applying our precision DNA synthesis to our Twist Antibody Optimization (TAO) toolbox, we can create customized phage display libraries that humanize and enhance your leads for improved affinity, developability, selectivity, and more. Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will transform your sequence into a personalized phage display library.

More Efficient Antibody Optimization

TAO uses a wide sequence space of 108 of natural human antibody sequences, creating an optimization library that precisely matches the human repertoire.

Concurrent Optimization Around Multiple Parameters

By precisely defining the sequence space explored, we can explicitly remove isomerization, cleavage, deamidation, glycosylation, and dipeptide liabilities. Simultaneously, Twist can also focus on humanizing leads, improving biophysical properties, and enhancing affinity and selectivity.

Built with Precision DNA Synthesis

Our rapid, scalable DNA synthesis platform enables quick generation of defined synthetic libraries, focused on the most relevant sequence space. We convert your lead antibody to the closest germline sequence and comprehensively explore the mutational space with unprecedented efficiency.

End-to-End Support for Antibody Development

Our DNA synthesis capabilities enable us to offer high-throughput conversion from scFv, Fab, or VHH formats to full-length IgG. Our team of antibody experts leverages their collective 50 years of experience to streamline development, with biophysical, and functional screening of any optimized leads