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Consistent library preparation from sheared DNA

Achieve unbiased DNA fragmentation with precise control over fragment size. The Twist Mechanical Fragmentation Library Prep Kit delivers consistent, reproducible library generation across a wide range of input DNA types and qualities, including degraded or low-quality samples, so you can trust your sequencing results from input to output. All required reagents are included to streamline the workflow and minimize hands-on time.

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Rapid workflow

Generate sequencer-ready libraries in just 2.5 hours.

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High-quality data

Identify genomic variants with higher confidence by reducing start- and stop-site artifacts.

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Supports multiple sample types

Achieve high-quality sequencing even from low-quality or degraded input DNA. Maintain reliable performance across a broad spectrum of sample types.

Twist's rationally sculpted libraries are unparalleled in quality and composition
Building a high-quality next generation sequencing (NGS) library starts long before sequencing. The Twist Mechanical Fragmentation Library Prep Kit workflow is engineered to give you precise control at every step, from how your DNA is fragmented, through adapter ligation and indexing, to a clean, amplified, sequencing-ready library. Whether you're starting with mechanically sheared genomic DNA (gDNA) or letting enzymatic chemistry handle fragmentation, both paths converge on the same outcome: consistent, reproducible libraries with exceptional on-target performance.
NGS library preparation workflow showing DNA fragmentation, adapter ligation, indexing, and amplification for high-quality sequencing-ready libraries

Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080