Developability Assessment

Identify Your Most Stable and
Manufacturable Leads

OVERVIEW
DATA
TECHNICAL RESOURCES

Antibody Development with the End in Mind

Developability parameters – such as solubility, stability, and aggregation – are a core component to define and advance a promising antibody lead.

At Twist Biopharma Solutions, we offer a comprehensive developability assessment package to complement our antibody production and broader antibody characterization offerings. Our flexible suite of chromatography, spectroscopy, and fluorimetry instruments provide valuable data to help you confidently select the most robust antibody candidates for downstream development and formulation.

Flexible Developability Assessment Packages

Size Exclusion Chromatography (SEC)

Cross-Interaction Chromatography (CIC)

Hydrophobic Interaction Chromatography (HIC)

Affinity-Capture Self-Interaction Nanoparticle Spectroscopy (AC-SINS)

Thermal Stability (Tm, Tonset, Tagg, rH, Tsize)

Reference Standards for Developability
Assessment

The figure above shows the performance of 12 reference standards using four of our developability assays. Each assay provides critical data on the interaction and behavior of antibody candidates, assisting in selecting the most promising leads for further development. The colored zones in each graph indicate different thresholds of acceptability for downstream development.