Optimizing the efficiency of next-generation sequencing (NGS) often involves targeted enrichment of genomic regions of interest prior to sequencing. In the Twist Bioscience target enrichment workflow, biotinylated synthetic DNA probes are designed to hybridize to exons or other custom genomic regions. Following hybridization with a genomic DNA sample, the probes are purified to produce a sample that is enriched for the targeted regions.
Twist Universal Blockers enhance the specificity of target capture by blocking non-specific hybridization between adapter sequences. Blocking non-specific interactions during hybridization simplifies experimental design and execution, reduces sequencing costs, and improves the results of targeted sequencing efforts.
Product Sheet
