Beacon-Based Single B Cell Screening

Consult with an in vivo Antibody DIscovery specialist

OVERVIEW
BENEFITS
TECHNICAL RESOURCES

Sequential Screening for Better Hits, Faster

The Beacon platform by Bruker Cellular Analysis is a disruptive, best-in-industry technology for single B cell screening. It enables high-resolution screening of antibody-secreting B cells with throughput and timeline previously unimaginable for antibody discovery.

Our scientists at Twist Biopharma Solutions are the first to adopt this state-of-the-art technology, meaning every obstacle or challenge has been tested and optimized to provide you with all the benefits this platform offers. Days after tissue collection, the Beacon provides a rich data set about each antibody screened to identify the rare and cross-reactive antibodies ideal for clinical development. Those antibodies are sequenced and rapidly expressed in-house to advance them to characterization and developability assays.

In vivo antibody discovery in weeks instead of months?

We do that. The Beacon-based B cell screening enables high-resolution screening for ideal, rare antibodies in previously impossible timelines.

Why is the Beacon Better?

The Beacon offers peak flexibility and resolution, evolved across 3 generations of single B cell screening technologies.

Our Expertise in Your Hands

Optimized Immunization and Screening Protocols

Immunization strategies with various animals
Choose our proprietary DiversimAb™ hyperimmune mouse
Proprietary protocols are optimized for single B cell screening
Assay components and reagent suite are optimized for specific applications
Species for each workflow are fully validated to ensure scientific excellence

Unparalleled Speed from Hit to Lead

Leverage the Beacon and our antibody discovery experts to rapidly discover high-quality antibodies with fewer wasted resources
Screen antibodies for the desired profiles such as specificity, cross-reactivity, blocking functionality, on-cell binding
Accelerate screening compared to the age-old method of developing and expressing hundreds or thousands of antibodies

Extensive Suite of On-Chip Screening Capabilities

Standard assay formats are offered such as cell binding and ligand blocking in addition to multiplexed assays such as species cross-reactivity and high-homology specificity
Twist has extensive experience validating complex assays on the Beacon platform
Our in vivo antibody discovery experts also offer custom assay development for validation assays

An End-to-End Discovery Workflow

The Beacon platform perfectly complements Twist’s in vivo antibody generation and characterization capabilities
Our integrated approach ensures scientific integrity and rigor throughout your entire discovery and development program
This allows us to anticipate and address any potential roadblocks to keep your projects on track and aligned with your goals

Technical Resources

DiversimAb™ Case Studies

Case Studies Biopharma

Rapid high-resolution screening of plasma B-cells to identify antibody lead candidates

App NoteBiopharma

DiversimAb™ Mouse for Antibody Discovery

Service Sheet Biopharma

Get in Touch With Us

Antibody enthusiasts are standing by and would love to hear more about your discovery needs. Challenging targets welcome!

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery