Library of Libraries

License Synthetic Libraries for In-House Antibody Discovery

OVERVIEW
BENEFITS
TECHNICAL RESOURCE

Quickly Generate High-Diversity, High-
Quality Molecules Inspired by the Human
Repertoire

Best-In-Class Synthetic Libraries Powered by Twist Technology

We are writing the future of biologics discovery with a best-in-class platform, our Library of Libraries, for hard-to-drug targets. Our collection of 17+ off-the-shelf libraries enables multiple pathways of discovery for your drug target of interest. We use our precision DNA synthesis technology to focus explicitly on the sequence space that will most benefit you and remove sequences associated with downstream developability and manufacturing liabilities.

Browse Our Library of Libraries

All Menus

Uncover Hits Against Virtually Any Target

Expand Your Discovery Opportunities

Our pre-constructed, validated phage display libraries are built using our precision DNA writing technology, allowing us to remove motifs that can lead to downstream manufacturing liabilities and focus only on the applicable sequence space. Twist Bioscience has designed multiple general, naïve, and target-focused libraries with diversities of 1010, giving you a multifaceted approach to your next discovery project.

Fast Antibody Discovery

Our collection of off-the-shelf libraries enables you to quickly identify high-quality leads against your target of interest using multiple strategies in only a few months. Libraries are available in various VHH, Fab, and scFv formats. These libraries can be leveraged to develop monoclonal antibodies, bi- or multi-specifics, and chimeric antigen receptors (CARs) for CAR-T cell therapy.

A Proven Discovery Engine

Internal discovery efforts using the library of libraries have led to the generation and optimization of lead antibody agonists, antagonists, and binders, with robust pre-clinical data packages. Our fully-humanized antibodies and VHH nanobodies are available for licensing. They make it possible to drug high-value targets in broad therapeutic areas, including immuno-oncology, oncology, metabolic diseases, and more.