Automation Solutions for
NGS Library Preparation
and Target Enrichment
Enabling genomics at scale through automation methods compatible
with the Twist workflow.
Maintain Consistency of Sample
Processing
Scale sample throughput without
impacting turnaround time
Reduce hands on time and manual
workflow steps
Optimize your lab's efficiency with expert
automation advice from Twist
The scale of sequencing utilization continues to grow at an exponential rate as platform capacity expands. Keeping your lab ready to keep up with pace through automation of library generation and target enrichment workflows is essential to meeting throughput demands.
Sometimes getting started can seem challenging, but Twist has you covered. We offer automation methods, resource files, and script templates to make increasing sample throughput simple and easy. Our reagents are automation-friendly for use on robotic liquid handling platforms and supported by team of NGS experts and automation specialists* ready to assist in optimizing workflows through collaboration with platform vendors. Contact us for consultation to adapt Twist NGS workflows to your laboratories specific requirements.
Reach out to your local Account Manager to discuss your
automation needs and how Twist can help!
Twist Automation Platform Resource Content
Beckman: Biomek® i5 8, Biomek® i7 8+96 and NGeniuS
Hamilton: NGS STAR™ 8 (LSA), NGS STAR™ 8+96 (MOA), STARV and VANTAGE
Agilent: Bravo B
Revvity: Sciclone NGSx
Tecan: Fluent/Dreamprep
Opentrons: Flex NGS
Complete Genomics: SP960 and SMART-8
Select a platform and reference the chart to determine which methods are demonstrated.
| PRODUCT |
|
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Vendor Sourced/Demonstrated |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Vendor Sourced/Demonstrated | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Vendor Sourced/Demonstrated | |
| Standard Hybridization 2.0 | Vendor Sourced/Demonstrated |
| METHYLATION | EM-seq™ | In Development |
| cfDNA | In Development | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Twist Demonstrated |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Twist Demonstrated | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Twist Demonstrated |
| Standard Hybridization 1.0 | Twist Demonstrated | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | In Development |
| Enzymatic Fragmentation 2.0 | In Development | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | In Development | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Vendor Sourced/Demonstrated |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Twist Demonstrated |
| Enzymatic Fragmentation 2.0 | Twist Demonstrated | |
| Mechanical Fragmentation | Twist Demonstrated | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | In Development |
| Standard Hybridization 1.0 | Twist Demonstrated | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | In Development |
| Enzymatic Fragmentation 2.0 | In Development | |
| Mechanical Fragmentation | In Development | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | In Development |
| Standard Hybridization 1.0 | Twist Demonstrated | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Vendor Sourced/Demonstrated |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Vendor Sourced/Demonstrated | |
| Standard Hybridization 2.0 | Vendor Sourced/Demonstrated |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Not Available |
| Enzymatic Fragmentation 2.0 | Partner Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Not Available | |
| Standard Hybridization 2.0 | Not Available |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | In Development | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Twist Demonstrated |
| Enzymatic Fragmentation 2.0 | Twist Demonstrated | |
| Mechanical Fragmentation | Twist Demonstrated | |
| RNA LIBRARY PREP | Library Prep | In Development |
| Library Prep with Depletion | In Development | |
| TARGET ENRICHMENT | Fast Hybridization | Twist Demonstrated |
| Standard Hybridization 1.0 | Twist Demonstrated | |
| Standard Hybridization 2.0 | Twist Demonstrated |
| METHYLATION | EM-seq™ | Twist Demonstrated |
| cfDNA | Twist Demonstrated | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Twist Demonstrated |
| Enzymatic Fragmentation 2.0 | Twist Demonstrated | |
| Mechanical Fragmentation | Twist Demonstrated | |
| RNA LIBRARY PREP | Library Prep | In Development |
| Library Prep with Depletion | In Development | |
| TARGET ENRICHMENT | Fast Hybridization | Twist Demonstrated |
| Standard Hybridization 1.0 | Twist Demonstrated | |
| Standard Hybridization 2.0 | Twist Demonstrated |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Not Available |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Vendor Sourced/Demonstrated | |
| Standard Hybridization 2.0 | Vendor Sourced/Demonstrated |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Not Available |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Not Available | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Not Available |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Vendor Sourced/Demonstrated | |
| Standard Hybridization 2.0 | In Development |
| METHYLATION | EM-seq™ | Not Available |
| cfDNA | Not Available | |
| DNA LIBRARY PREP | Enzymatic Fragmentation 1.0 | Not Available |
| Enzymatic Fragmentation 2.0 | Vendor Sourced/Demonstrated | |
| Mechanical Fragmentation | Not Available | |
| RNA LIBRARY PREP | Library Prep | Not Available |
| Library Prep with Depletion | Not Available | |
| TARGET ENRICHMENT | Fast Hybridization | Not Available |
| Standard Hybridization 1.0 | Vendor Sourced/Demonstrated | |
| Standard Hybridization 2.0 | Vendor Sourced/Demonstrated |
Twist products and services may not be available in all regions or geographies. Please reach out to your Twist representative for offerings in your region.
Methods and Scripts from
Key Automation Vendors
Consultation for workflow
development and troubleshooting issues
Twist Reagents compatibility with
workflows for validated protocols
Contact Twist’s Team today to get started
with your automation project
Download our poster
In this poster, we describe the automation of Twist Bioscience’s highly modular library preparation and hybridization-capture targeted enrichment chemistries with the use of the Twist Human Core Exome panel on the Beckman Coulter Biomek i7 Hybrid liquid handling platform.
FAQ
Automation Support on the listed platforms is not available in all regions globally.
