Well Characterized Antibodies To Get From Hit to Lead
Biological activity and determining the MoA for your lead antibodies can be the final step before moving into in vivo testing.
Twist Biopharma Solutions’ scientific experts use off-the-shelf or can develop custom cell-based assays to put your biochemical and biophysical data in context. Along with our high-throughput antibody expression and robust portfolio of characterization services and exceptional track record, we can help you make an informed decision about which leads will give you the greatest chance of preclinical success.
Well Characterized Antibodies To Get From Hit to Lead
Biological activity and determining the MoA for your lead antibodies can be the final step before moving into in vivo testing.
Twist Biopharma Solutions’ scientific experts use off-the-shelf or can develop custom cell-based assays to put your biochemical and biophysical data in context. Along with our high-throughput antibody expression and robust portfolio of characterization services and exceptional track record, we can help you make an informed decision about which leads will give you the greatest chance of preclinical success.
Uncover Hits Against Virtually Any Target
Flexible Testing for Your Needs
Our antibody experts offer various common off-the-shelf signaling assays focused on GPCRs and pathways that are important for immunology and immuno-oncoloy applications, including:
GPCR SIGNALLING
cAMP reporter assay and β-arrestin reporter assay
INTERNALIZATION
NFKB LUCIFERASE ASSAY
NFAT LUSIFERASE ASSAY
AP1 LUCIFERASE ASSAY
WNT LUCIFERASE ASSAY
TCF/LEF LUCIFERASE ASSAY
Specialized Immune Assays
We also conduct specialized immune assays for T-cell, B-cell, dendritic cell, natural killer cell, and macrophage: Our functional assays team can also develop a custom assay that fits your program’s needs.
CYTOKUNE RELEASE
CYTOTOXICITY
ACTIVATION
PHAGOCYTOSIS
PROLIFERATION
Complementary Services for Therapeutic Antibody Development
Antibody production, affinity assessment, epitope binning, and developability assessment play crucial roles alongside the functional testing of a candidate antibody. Twist offers these services as an integrated end-to-end discovery workflow or as a standalone service, providing you with the format that fits your needs best. Together, these services create a comprehensive picture of an antibody's therapeutic potential, guiding you toward the most promising candidates for preclinical and clinical studies.
Uncover Hits Against Virtually Any Target
Flexible Testing for Your Needs
Our antibody experts offer various common off-the-shelf signaling assays focused on GPCRs and pathways that are important for immunology and immuno-oncoloy applications, including:
GPCR SIGNALLING
cAMP reporter assay and β-arrestin reporter assay
INTERNALIZATION
NFKB LUCIFERASE ASSAY
NFAT LUSIFERASE ASSAY
AP1 LUCIFERASE ASSAY
WNT LUCIFERASE ASSAY
TCF/LEF LUCIFERASE ASSAY
Specialized Immune Assays
We also conduct specialized immune assays for T-cell, B-cell, dendritic cell, natural killer cell, and macrophage: Our functional assays team can also develop a custom assay that fits your program’s needs.
CYTOKUNE RELEASE
CYTOTOXICITY
ACTIVATION
PHAGOCYTOSIS
PROLIFERATION
Complementary Services for Therapeutic Antibody Development
Antibody production, affinity assessment, epitope binning, and developability assessment play crucial roles alongside the functional testing of a candidate antibody. Twist offers these services as an integrated end-to-end discovery workflow or as a standalone service, providing you with the format that fits your needs best. Together, these services create a comprehensive picture of an antibody's therapeutic potential, guiding you toward the most promising candidates for preclinical and clinical studies.
Looking for a specific assay or interested in designing a custom program with our antibody engineers?
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Get in Touch With Us
Antibody enthusiasts are standing by and would love to hear more about your discovery needs. Challenging targets welcome!
