Diversity SNP Panel

As the first release in Twist’s emerging Targeted Genotyping-By-Sequencing (GBS) portfolio, the Twist Diversity SNP panel leverages Twist’s best-in-class DNA synthesis platform to generate a global panel of more than 600,000 probes governing approximately 1.4 million SNPs.

Used separately as a stand-alone genotyping panel or as a spike-in into Twist’s Human Comprehensive Exome panel, this assay gives researchers a new ethnicity-neutral gold standard to use in generating genotyping data to match with their sequencing and other genomic data. 

Compared to historical microarray platforms that offer fixed content updated occasionally, the Twist Diversity SNP panel allows scientists the freedom to choose between standardized catalogue content or - with Twist’s custom NGS probes capabilities - the ability to build upon this foundation with additional regions of interest, creating unique content for any focused disease research application. For higher throughput users, this approach also enables improved scale-up economics with no requirement for additional capital investment.

The Twist Diversity SNP Panel content was curated in partnership with leaders at the Regeneron Genetics Center. Designed to integrate into existing fully automated exome processing workflows, this panel provides base calls and imputed variants.

Genotype imputations can be calculated using open source tools available. Please reach out to Customer Support to get a copy of our imputation guide to get started with imputation analysis tools.

*Note: The Diversity SNP panel content has not been fully validated through the complete Twist workflow. For recommendations on assay set-up, please contact Twist Customer Support.