NEW PRODUCTS VIRUS DETECTION ANTIBODY DEVELOPMENT RESOURCES
NEW PRODUCTS

The recent Coronavirus pandemic has led to a rapid response from the viral research and therapeutics community around the world.  These research teams need robust and reliable genomic tools to classify and characterize viral samples, and genome engineering tools to build vaccines to help stop the spread of this deadly virus.  

Twist’s unique silicon-based DNA writing platform allows for the rapid development of NGS panels for viral detection and characterization of samples, and our Clonal Genes and Gene Fragments allow for quick development of subunit vaccines from one or more antigen-presenting viral genes or peptide sequences, which bypasses the need for scientists to handle live and potentially dangerous pathogens, and minimizes the time needed to clone DNA fragments.

Now Available - Synthetic Controls for Variant Strains Alpha, Beta, Gamma, Delta, and Omicron (B.1.1.7, B.1.351, P.1, B.1.617.2, AY.1, AY.2 B.1.1.529 BA.1, B.1.1.529 BA.2)

In response to the ongoing emergence of new SARS-CoV-2 strains, Twist has expanded its Synthetic RNA Control portfolio, adding the following controls that cover the new strains that are rapidly becoming the dominant variants around the world. These highly infectious strains of SARS-CoV-2 exhibit significant changes across their genomes including changes to the spike protein coding region. These changes can render some RT-PCR probes used widely in COVID-19 testing invalid for detection of the S gene.

Twist has added four new Synthetic Controls that cover these variants. The Synthetic RNA Controls provide quality control measures for a wide range of applications including the verification and validation of diagnostic tests of both next-generation sequencing (NGS) and RT-PCR assays.

Products:

Control 2 Wuhan-Hu-1

Control 14 England/205041766/2020 (B.1.1.7 lineage)

Control 15 England/MILK-9E05B3/2020 (B.1.1.7 lineage)

Control 16 South Africa/KRISP-EC-K005299/2020 (B.1.351 lineage)

Control 17 Japan/IC-0564/2021 (P.1 lineage)

Control 18 Kappa (B.1.617.1 lineage) India/CT-ILSGS00361/202

Control 23 Delta (B.1.617.2 lineage) India/MH-NCCS-P1162000182735/2021

Control 24 (B.1.617.3 lineage) India/MH-SEQ-221_S66_R1_001/2021

Control 28 Delta (AY.1 lineage) Portugal/PT9543/2021

Control 29 Delta (AY.2 lineage) USA/WA-CDC-UW21061750277/2021

Control 48 Omicron (B.1.1.529, BA.1 lineage) Hong Kong/HKU-211129-001/2021

Control 50 Omicron (B.1.1.529, BA.2 lineage) Australia/QLD2568/2021

Control 51 Omicron (B.1.1.529, BA.2 lineage) England/MILK-2DF642C/2021 

 

Learn More

COVID-19 Antibodies

Antibodies targeting the SARS-CoV-2 Spike Protein and human ACE2 have been developed using Twist Biopharma’s variant library generation and screening capabilities. Data and information about these antibodies can be found at the link below. 

Antibodies for COVID-19

Comprehensive Viral Research Panel

The Twist Comprehensive Viral Research Panel offers a complete target enrichment solution that allows researchers to quickly identify and characterize novel and highly evolved viruses in a variety of sample types. It covers reference sequences for 3,153 viruses, including 15,488 different strains.

Related Resources:

Learn More

Respiratory Virus Research Panel

The Twist Respiratory Virus Research Panel allows for detection of multiple viral pathogens from a single sample, detecting as little as 100 copies of viral material per virus. Coupled with analysis by One Codex, researchers can generate reports with viral species identification and create publication-ready visualizations.

Products:
Related Resources:

Respiratory Virus Controls

The Twist Respiratory Virus Controls enable investigation into the biology of a broad range of viruses by NGS and qPCR. Included in the panel is a range of variants with comprehensive coverage of full length synthetic virus sequences, enabling distinction between key infectious agents.

Related Resources:

ORder Now

Synthetic SARS-CoV-2 RNA Controls

Positive controls provide quality control measures for the verification and validation for point-of-care diagnostic tests including both next-generation sequencing (NGS) and reverse transcriptase-polymerase chain reaction (RT-PCR) assays. Twist offers fully synthetic SARS-CoV-2 RNA controls, available for multiple distinct reference sequences.

Learn More

Related Resources:

SARS-CoV-2 Research Panels

In addition to the robust RNA standards, Twist also offers Research-Use Only (RUO) target enrichment NGS panels for viral detection and characterization of samples. These panels can be used for environmental monitoring and surveillance testing, while also providing insight into full sequence information for monitoring of viral evolution and strain origin.

Products:
Related Resources:

To order these products please click button below and be sure to sign up for an account or login to our online ordering platform.

order Now

 

Additional Resources:

Read our latest blog post on Building the Raw Materials to Tackle Coronavirus

Watch now: Why labs are printing the Coronavirus genome

 

WRITING THE FUTURE OF COVID-19 THERAPIES

Learn about how Dr. Aaron Sato Twist’s CSO and leader of our Biopharma division is building antibody therapeutics to address COVID-19 infection.

Watch the Webinar

Twist COVID-19 antibody for therapeatic and diagnostic development

VIRUS DETECTION
ANTIBODY DEVELOPMENT
RESOURCES