At Twist, we have developed a filter to remove probes which have significant overlap with repetitive genomic elements (eg. SINE/LINE). Removal of these probes is necessary as they can negatively impact panel performance by capturing unwanted off-target regions. Repeat Filtering Stringency determines the filter's stringency for removing probes that overlap with highly repetitive genomic elements. Options include High, Medium (default), and Low stringency.  We advise users to stick with our default recommendation of Medium.