Human Core Exome

OVERVIEW

The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.

KEY BENEFITS

Exceptional performance

High fidelity double stranded DNA probes with optimized performance

NGS QC of all probes

Uniform enrichment of target regions

Greater flexibility

Customization tools allow the rapid and scalable implementation of custom exomes

Modular kit structure enables workflow flexibility for easy integration into existing protocols

Maximized sequencing efficiency

Increased depth per sample or more samples per run

Lower sequencing costs

EXOME DEFINITION

33 Mb CCDS coverage

99% of ClinVar variants covered

99.3% of targeted regions covered at 20x with 5.3 Gb

The NGS Human Core Exome provides the ability to lower sequencing costs, increase sample throughput, and achieve a higher depth of coverage across target regions with uncompromising quality.

KEY BENEFITS

Exceptional performance

High fidelity double stranded DNA probes with optimized performance

NGS QC of all probes

Uniform enrichment of target regions

Greater flexibility

Customization tools allow the rapid and scalable implementation of custom exomes

Modular kit structure enables workflow flexibility for easy integration into existing protocols

Maximized sequencing efficiency

Increased depth per sample or more samples per run

Lower sequencing costs

EXOME DEFINITION

33 Mb CCDS coverage

99% of ClinVar variants covered

99.3% of targeted regions covered at 20x with 5.3 Gb

DATA

Uncompromised Performance

Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.

Efficient Read Usage

Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate

Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth.

Uncompromised Performance

Twist Human Core Exome Kit resulted in a higher number of targets covered with 20 or 30 reads compared to leading competitors.

Efficient Read Usage

Twist Bioscience provides higher library complexity than the competitor kits resulting in a lower duplication rate

Run more samples with the same budget

The improved coverage uniformity of the Twist Human Core Exome reduces the amount of sequencing required to achieve the desired coverage depth.

CUSTOMIZATION

Customization of Core Exome Kit Content and Components

The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.

Additional content with high enrichment uniformity
Increased coverage of specific genes covered by Core Exome
Optimization of spike-in ratio by customer

Customization of Core Exome Kit Content and Components

The ability to simply add your spike-in panel to the Core Exome creates added differentiation based on your research requirements. Rapid design optimization with a quick production turnaround reduces overall development time for your custom exome.