群体基因组学研究唯一适于识别人类基因组中的罕见多基因模式，可为疾病的遗传驱动因素和我们复杂的进化史提供宝贵的见解。
Twist Bioscience has developed a genotyping panel design pipeline using a novel and proprietary algorithm that optimizes capture efficiency according to target binding thermodynamics.
The Twist Genotyping Panel - Human 600k has been optimized to enrich over 600,000 genetic variants (covering commonly used variants in genotyping assays for population screening studies). Twist Bioscience 还提供定制的靶向富集芯片和设计支持，以捕获您的主要靶标位点。
新一代测序与传统变异筛选研究平台的优势对比
FEATURE |
NGS (Next-Generation Sequencing) |
Traditional Microarrays |
|---|---|---|
|
Data Completeness and Scalability |
Offers scalability for variant screening studies and genomic information beyond single nucleotide polymorphisms (SNPs). |
Limited in scalability and may not provide comprehensive data coverage. |
|
Customization of Content |
Enables easy customization of genotyping content using target enrichment panels. |
Customization is limited to predefined probe sets and arrays. |
|
Cost and Throughput |
Paired with Twist’s FlexPrep™ UHT Library Preparation Kit, NGS can overcome barriers related to cost per sample and throughput. |
Requires low upfront cost but can be less cost-effective for large-scale or deep studies |
群体基因组学研究唯一适于识别人类基因组中的罕见多基因模式，可为疾病的遗传驱动因素和我们复杂的进化史提供宝贵的见解。
Twist Bioscience has developed a genotyping panel design pipeline using a novel and proprietary algorithm that optimizes capture efficiency according to target binding thermodynamics.
The Twist Genotyping Panel - Human 600k has been optimized to enrich over 600,000 genetic variants (covering commonly used variants in genotyping assays for population screening studies). Twist Bioscience 还提供定制的靶向富集芯片和设计支持，以捕获您的主要靶标位点。
新一代测序与传统变异筛选研究平台的优势对比
FEATURE |
NGS (Next-Generation Sequencing) |
Traditional Microarrays |
|---|---|---|
|
Data Completeness and Scalability |
Offers scalability for variant screening studies and genomic information beyond single nucleotide polymorphisms (SNPs). |
Limited in scalability and may not provide comprehensive data coverage. |
|
Customization of Content |
Enables easy customization of genotyping content using target enrichment panels. |
Customization is limited to predefined probe sets and arrays. |
|
Cost and Throughput |
Paired with Twist’s FlexPrep™ UHT Library Preparation Kit, NGS can overcome barriers related to cost per sample and throughput. |
Requires low upfront cost but can be less cost-effective for large-scale or deep studies |
Figure 1a: Twist Genotyping Panel - Human 600k achieves high concordance with deep WGS data. At 1 Gb, the hybrid capture approach achieved 99.46%(IQR: 99.18-99.74%) concordance to deep while genome sequencing data. Standard variant calling yielded a concordance of 93.56%(IQR: 93.32-93.80%).
Figure 1b: Twist Genotyping Panel - Human 600k achieves high concordance with array data. Genomewide non-reference concordance (NRC) obtained after imputing all data (sequencing or array) to the Gencove v6.1 imputation reference panel.
Figure 1a: Twist Genotyping Panel - Human 600k achieves high concordance with deep WGS data. At 1 Gb, the hybrid capture approach achieved 99.46%(IQR: 99.18-99.74%) concordance to deep while genome sequencing data. Standard variant calling yielded a concordance of 93.56%(IQR: 93.32-93.80%).
Figure 1b: Twist Genotyping Panel - Human 600k achieves high concordance with array data. Genomewide non-reference concordance (NRC) obtained after imputing all data (sequencing or array) to the Gencove v6.1 imputation reference panel.
110522
Twist 基因分型组合 - 人 600k，2 个反应110523
Twist 基因分型组合 - 人 600k，12 个反应110619
Twist 基因分型组合 - 人 600k，96 个反应109220
Twist FlexPrep UHT 文库制备试剂盒，192 个样本109223
Twist FlexPrep UHT LP 和杂交试剂盒，192 个样本*Twist 网站和产品的使用受 Twist 条款和条件的约束，仅供研究使用。
110522
Twist 基因分型组合 - 人 600k，2 个反应110523
Twist 基因分型组合 - 人 600k，12 个反应110619
Twist 基因分型组合 - 人 600k，96 个反应109220
Twist FlexPrep UHT 文库制备试剂盒，192 个样本109223
Twist FlexPrep UHT LP 和杂交试剂盒，192 个样本*Twist 网站和产品的使用受 Twist 条款和条件的约束，仅供研究使用。
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