What is Critical Reagents and Tool Antibodies?
Across antibody discovery and development spectrum, you need high-quality proteins, cell lines, DNA, and other critical reagents to confidently strategize your immunization, screening, functional characterization, and optimization protocols. This is critical to the selection of potent, safe, and efficacious biotherapeutics. Generating these reagents and tool antibodies such as Anti-Ids for your development campaigns with highly qualified and robust workflows and starts with a trusted, experienced, and attentive partner.
What is Critical Reagents and Tool Antibodies?
Across antibody discovery and development spectrum, you need high-quality proteins, cell lines, DNA, and other critical reagents to confidently strategize your immunization, screening, functional characterization, and optimization protocols. This is critical to the selection of potent, safe, and efficacious biotherapeutics. Generating these reagents and tool antibodies such as Anti-Ids for your development campaigns with highly qualified and robust workflows and starts with a trusted, experienced, and attentive partner.
抗独特型抗体发现服务
At Twist Biopharma Solutions, we approach your drug development endeavors with the end goal in mind. Anti-idiotypic (anti-ids) antibodies play a pivotal role in the preclinical journey by serving as valuable reagents for quality control, ensuring the specificity and efficacy of therapeutic antibodies. These antibody tools are essential for assessing the immunogenicity and safety profiles of biologics, aiding in the detection of unwanted immune responses and ultimately accelerating the development of novel therapies with improved efficacy and safety profiles.
丰富的抗体多样性
Twist's platform produces a diverse panel of target specific anti-idiotypic antibodies using our proprietary hyperimmune DiversimAb™ Mouse.
高级亲和力和特异性筛选
Industry-leading, function-forward screening packages offer anti-ids stringently screened for binding affinity in the presence of human serum using both ELISA and BLI to deliver ideal antibodies ready for validation assays.
快速、可预测的项目进程
Twist devises an industry-leading anti-idiotypic antibody discovery platform that offers either single B-cell screening or integrated hybridoma workflows to de-risk projects and improve the predictability of timelines.
Proven Expertise and 97% Success Rate
250+ successful anti-idiotypic antibody programs.
97% success rate based on project requirements.
Success in different therapeutic modalities, including monoclonal antibodies, bispecifics, ADCs, and cell therapy products.
什么是抗独特型抗体？
Anti-idiotypic antibodies are antibodies that bind to the idiotype of another antibody or biologic, typically an antibody drug. Anti-ids are important downstream reagents for specific drug development assays (e.g. PK and ADA), as well as many other applications such as diagnostic assays and biomarker discovery and evaluation.
There are different ways an anti-idiotypic antibody can interact with an antibody via different regions. 成功开发的关键因素在于了解预期应用并设计适当的筛选标准，以选择理想的抗独特型抗体。Twist Biopharma Solutions develops industry-leading technologies and workflows that will drastically enhance the success of anti-idiotypic antibody discovery campaigns.
Anti-Idiotypic Antibody Workflows, Customized for your Development Program
Twist’s Anti-Id Guarantee
Our anti-idiotypic guarantee promises delivery of anti-idiotypic antibodies capable of binding
specifically to your target biologic. If we don’t find at least one antibody that’s specific to your target,
we will perform an additional screen for FREE.
抗独特型抗体发现服务
At Twist Biopharma Solutions, we approach your drug development endeavors with the end goal in mind. Anti-idiotypic (anti-ids) antibodies play a pivotal role in the preclinical journey by serving as valuable reagents for quality control, ensuring the specificity and efficacy of therapeutic antibodies. These antibody tools are essential for assessing the immunogenicity and safety profiles of biologics, aiding in the detection of unwanted immune responses and ultimately accelerating the development of novel therapies with improved efficacy and safety profiles.
丰富的抗体多样性
Twist's platform produces a diverse panel of target specific anti-idiotypic antibodies using our proprietary hyperimmune DiversimAb™ Mouse.
高级亲和力和特异性筛选
Industry-leading, function-forward screening packages offer anti-ids stringently screened for binding affinity in the presence of human serum using both ELISA and BLI to deliver ideal antibodies ready for validation assays.
快速、可预测的项目进程
Twist devises an industry-leading anti-idiotypic antibody discovery platform that offers either single B-cell screening or integrated hybridoma workflows to de-risk projects and improve the predictability of timelines.
Proven Expertise and 97% Success Rate
250+ successful anti-idiotypic antibody programs.
97% success rate based on project requirements.
Success in different therapeutic modalities, including monoclonal antibodies, bispecifics, ADCs, and cell therapy products.
什么是抗独特型抗体？
Anti-idiotypic antibodies are antibodies that bind to the idiotype of another antibody or biologic, typically an antibody drug. Anti-ids are important downstream reagents for specific drug development assays (e.g. PK and ADA), as well as many other applications such as diagnostic assays and biomarker discovery and evaluation.
There are different ways an anti-idiotypic antibody can interact with an antibody via different regions. 成功开发的关键因素在于了解预期应用并设计适当的筛选标准，以选择理想的抗独特型抗体。Twist Biopharma Solutions develops industry-leading technologies and workflows that will drastically enhance the success of anti-idiotypic antibody discovery campaigns.
Anti-Idiotypic Antibody Workflows, Customized for your Development Program
Twist’s Anti-Id Guarantee
Our anti-idiotypic guarantee promises delivery of anti-idiotypic antibodies capable of binding
specifically to your target biologic. If we don’t find at least one antibody that’s specific to your target,
we will perform an additional screen for FREE.
Custom Antigen Production and Design
The quality of your antigen is critical to the success of every antibody discovery project. At Twist Biopharma Solutions, we’ve built our antigen production capabilities to offer a reliable source of high-quality reagents and give our clients flexibility without sacrificing a streamlined workflow.
我们的分子生物学团队在为抗体发现研究提供试剂方面拥有丰富的经验。We have also optimized our immunization techniques to generate robust immune responses to difficult target classes.
基因到蛋白质的重组抗原开发
Using our industry-leading team of cell culture, purification, and analytical experts, we generate high-purity research-grade proteins or antibodies delivered on time to meet your exacting expectations. Equipped with state-of-the-art and high-throughput cell culture and purification systems, we produce a wide array of proteins to support your research goals.
细胞系生成
We have incorporated transient cell line generation to meet your needs and continue to provide robust cell-based antibody discovery services. Our transient approach allows for quick and efficient success in our discovery campaigns.
多肽和小分子抗原
Our immunization expertise enables us to make highly specific, high-affinity antibodies against peptides and small molecules that may not be immunogenic in other in vivo systems.
现成的抗原
Our commercial collaboration with Acro Biosystems allows you to access thousands of recombinant proteins on expedited timelines. Having a high-quality, trustworthy provider allows projects to start faster.
Custom Antigen Production and Design
The quality of your antigen is critical to the success of every antibody discovery project. At Twist Biopharma Solutions, we’ve built our antigen production capabilities to offer a reliable source of high-quality reagents and give our clients flexibility without sacrificing a streamlined workflow.
我们的分子生物学团队在为抗体发现研究提供试剂方面拥有丰富的经验。We have also optimized our immunization techniques to generate robust immune responses to difficult target classes.
基因到蛋白质的重组抗原开发
Using our industry-leading team of cell culture, purification, and analytical experts, we generate high-purity research-grade proteins or antibodies delivered on time to meet your exacting expectations. Equipped with state-of-the-art and high-throughput cell culture and purification systems, we produce a wide array of proteins to support your research goals.
细胞系生成
We have incorporated transient cell line generation to meet your needs and continue to provide robust cell-based antibody discovery services. Our transient approach allows for quick and efficient success in our discovery campaigns.
多肽和小分子抗原
Our immunization expertise enables us to make highly specific, high-affinity antibodies against peptides and small molecules that may not be immunogenic in other in vivo systems.
现成的抗原
Our commercial collaboration with Acro Biosystems allows you to access thousands of recombinant proteins on expedited timelines. Having a high-quality, trustworthy provider allows projects to start faster.
听听科学家们怎么说
I can always trust that I’ll have no surprises when I’m working with the Twist Biopharma Solutions team, and that’s why I continue to come back. I’ve outsourced dozens of anti-id programs during my career and there have been too many times where simple oversights have cost me 6+ months in assay development. For these high-impact translational programs, it’s critical we get it right the first time.”
Director of Translational Development
Biopharma
在 Promega，我们非常想要获得针对一个靶标的高亲和力、高特异性抗体。After failing with two previous vendors, we enlisted the help of Twist Biopharma Solutions and their DiversimAb approach, and we soon had a multitude of high-quality clones to choose from. 我们最终选择了一个远远超出我们预期的高性能克隆产品。We were continually impressed by their high-quality analytical data, excellent communication, and overall collaborative spirit.”
Promega Corporation
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