概述

Precision DNA Synthesis Paired with Multi-Parameter Optimization

The antibody optimization process requires designing and testing many combinations of antibody variants to narrow in on a developable, functional, optimal candidate.

Applying our precision DNA synthesis to our Twist Antibody Optimization (TAO) toolbox, we can create customized phage display libraries that humanize and enhance your leads for improved affinity, developability, selectivity, and more. Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will transform your sequence into a personalized phage display library.

 

曲线图

 

 

Precision DNA Synthesis Paired with Multi-Parameter Optimization

The antibody optimization process requires designing and testing many combinations of antibody variants to narrow in on a developable, functional, optimal candidate.

Applying our precision DNA synthesis to our Twist Antibody Optimization (TAO) toolbox, we can create customized phage display libraries that humanize and enhance your leads for improved affinity, developability, selectivity, and more. Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will transform your sequence into a personalized phage display library.

 

曲线图

 

 

优势

More Efficient Antibody Optimization

TAO uses a wide sequence space of 108 of natural human antibody sequences, creating an optimization library that precisely matches the human repertoire.

Concurrent Optimization Around Multiple Parameters

By precisely defining the sequence space explored, we can explicitly remove isomerization, cleavage, deamidation, glycosylation, and dipeptide liabilities. Simultaneously, Twist can also focus on humanizing leads, improving biophysical properties, and enhancing affinity and selectivity.

采用精确的 DNA 合成技术构建

Our rapid, scalable DNA synthesis platform enables quick generation of defined synthetic libraries, focused on the most relevant sequence space. We convert your lead antibody to the closest germline sequence and comprehensively explore the mutational space with unprecedented efficiency.

为抗体开发提供端到端的支持

Our DNA synthesis capabilities enable us to offer high-throughput conversion from scFv, Fab, or VHH formats to full-length IgG. Our team of antibody experts leverages their collective 50 years of experience to streamline development, with biophysical, and functional screening of any optimized leads.

为抗体开发提供端到端的支持

曲线图

More Efficient Antibody Optimization

TAO uses a wide sequence space of 108 of natural human antibody sequences, creating an optimization library that precisely matches the human repertoire.

Concurrent Optimization Around Multiple Parameters

By precisely defining the sequence space explored, we can explicitly remove isomerization, cleavage, deamidation, glycosylation, and dipeptide liabilities. Simultaneously, Twist can also focus on humanizing leads, improving biophysical properties, and enhancing affinity and selectivity.

采用精确的 DNA 合成技术构建

Our rapid, scalable DNA synthesis platform enables quick generation of defined synthetic libraries, focused on the most relevant sequence space. We convert your lead antibody to the closest germline sequence and comprehensively explore the mutational space with unprecedented efficiency.

为抗体开发提供端到端的支持

Our DNA synthesis capabilities enable us to offer high-throughput conversion from scFv, Fab, or VHH formats to full-length IgG. Our team of antibody experts leverages their collective 50 years of experience to streamline development, with biophysical, and functional screening of any optimized leads.

为抗体开发提供端到端的支持

曲线图

技术资源

技术资源

TAO:抗 PD-1 抗体的 Twist 抗体优化

Case StudiesBiopharma

Download the case studies

Twist Antibody Optimization Platform

产品表单生物制药

Download the service sheet

技术资源

TAO:抗 PD-1 抗体的 Twist 抗体优化

Case StudiesBiopharma

Download the case studies

Twist Antibody Optimization Platform

产品表单生物制药

Download the service sheet

联系我们

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