Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Cell, Dec 2020 | 183 (7), 1884-1900.e23

DOI: 10.1016/j.cell.2020.11.011

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Williamson, Lauren E ; Gilliland, Theron ; Yadav, Pramod K ; Binshtein, Elad ; Bombardi, Robin ; Kose, Nurgun ; Nargi, Rachel S ; Sutton, Rachel E ; Durie, Clarissa L ; Armstrong, Erica ; Carnahan, Robert H ; Walker, Lauren M ; Kim, Arthur S ; Fox, Julie M ; Diamond, Michael S ; Ohi, Melanie D ; Klimstra, William B ; Crowe, James E

PRODUCTS USED

Genes

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ABSTRACT

Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we characterize human monoclonal antibodies (mAbs) isolated from a survivor of natural EEEV infection with potent (

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PRODUCTS USED

Genes

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery