Iterate your AI models without bottlenecks with reproducible binding and developability in weeks
How we can help
Generate more sequences, move faster, and get model-ready data without taking on the complexity of protein production, assay execution, or data generation.
Who we serve
Whether you're building the next foundation model or advancing a clinical lead, Twist has a path for you.
Twist connects sequence generation to documented, model-ready data through an integrated suite of products and services.
Input your sequences from your Gen AI platforms to generate DNA or protein production for wet-lab validation.
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With high-quality datasets, researchers can train and refine their AI models. Validate those models with Twist Express Antibodies and high-throughput characterization services to generate data from sequences in as few as 15 days.
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Twist enables the validation of your AI outputs for thousands of proteins for binding and developability characteristics. Twist offers custom data delivery formats that are benchmarked against clinical antibody controls to ensure high-quality datasets ready for direct use in your AI and machine learning models.
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Twist connects your sequences to documented and predictable data sets that you can use to integrate into your models improve your drug discovery and development efforts. Need help designing a program or interpreting your data?
Speak to an expertWhy Twist
Others can only provide binding confirmation. Twist delivers the full developability picture: every data type your AI model needs to train, rank, and advance leads to clinical validation.
Full kinetic characterization across a concentration series with global $K_D$ fits (Blue: data; Red: fit).
Evaluate binding to multiple cell lines at a single concentration or in a or in a concentration series to calculate on cell affinity, or EC50.
Identify antibody communities and distinct binding epitopes via classical SPR cross-competition for diverse lead selection.
Benchmark manufacturing feasibility and sample quality by quantifying production yield, monomeric purity (aSEC), and particle size distribution (DLS).
Assess biophysical properties including thermal stability (Tm, Tagg) and monodispersity to help rank order based on stability and aggregation propensity.
Evaluate developability risk by quantifying off-target binding and self-association via BVP-ELISA and AC-SINS profiling.
Excellent assay correlation between high-throughput HIC versus HPLC HIC with IgG and VHH-Fc standards. A similar correlation is observed for plate-based CIC.
Customizable assay platforms to evaluate functional potency and mechanism of action across multiple cell types.
Tell us where you are in your AI drug discovery journey. Our scientific team will reach out within one business day to discuss how Twist can accelerate your work.
For Research Use Only. Not for use in diagnostic procedures.
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Genes
Oligo Pools
NGS
Variant Libraries
Antibody Discovery
IVDR Solutions
