Autologous neutralizing antibody responses after antiretroviral therapy in acute and early HIV-1

The Journal of clinical investigation, Apr 2024

DOI: 10.1172/JCI176673

Autologous neutralizing antibody responses after antiretroviral therapy in acute and early HIV-1

Whitehill, Gregory D ; Joy, Jaimy ; Marino, Francesco E ; Krause, Ryan J ; Mallick, Suvadip ; Courtney, Hunter M ; Park, Kyewon ; Carey, John W ; Hoh, Rebecca ; Hartig, Heather ; Pae, Vivian ; Sarvadhavabhatla, Sannidhi ; Donaire, Maria Sophia B ; Deeks, Steven G ; Lynch, Rebecca M ; Lee, Sulggi A ; Bar, Katharine J

PRODUCTS USED

Genes

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ABSTRACT

Early antiretroviral therapy initiation (ARTi) in HIV-1 restricts reservoir size and diversity while preserving immune function, potentially improving opportunities for immunotherapeutic cure strategies. For antibody-based cure approaches, the development of autologous neutralizing antibodies (anAb) after acute/early ARTi is relevant, but poorly understood.We characterize antibody responses in a cohort of 23 participants following ARTi in acute HIV (

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PRODUCTS USED

Genes

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery