11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes

Research Square, Dec 2021

DOI: 10.21203/rs.3.rs-1179128/v1

11C-metomidate PET CT versus Adrenal Vein Sampling for diagnosing surgically curable primary aldosteronism: prospective test validation, and impact of somatic genotype and ethnicity on outcomes

Wu, Xilin ; Senanayake, Russell ; Goodchild, Emily ; Bashari, Waiel ; Salsbury, Jackie ; Cabrera, Claudia ; Argentesi, Giulia ; O'Toole, Samuel ; Matson, Matthew ; Koo, Brendan ; Parvanta, Laila ; Hilliard, Nick ; Kosmoliaptsis, Vasilis ; Marker, Alison ; Berney, Daniel ; Wen, Wilson Tan Lek ; Foo, Roger ; Mein, Charles ; Wozniak, Eva ; Savage, Emmanuel ; Sahdev, Anju ; Bird, Nicholas ; Laycock, Kate ; Boros, Istvan ; Hader, Stefan ; Warnes, Victoria ; Gillett, Dan ; Dawnay, Anne ; Adeyeye, Elizabeth ; Prete, Alessandro ; Taylor, Angela ; Arlt, Wiebke ; Bhuva, Anish ; Aigbirhio, Franklin ; Manisty, Charlotte ; McIntosh, Alasdair ; McConnachie, Alex ; Cruickshank, J. Kennedy ; Cheow, Heok ; Gurnell, Mark ; Drake, William ; Brown, Morris

PRODUCTS USED

NGS

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ABSTRACT

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma (APA) is a common, curable cause of hypertension, but invasive methods of diagnosis and treatment contribute to -17%, the pre-specified margin of non-inferiority. The best univariate predictors of complete clinical cure were home systolic blood pressure (SBP)

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PRODUCTS USED

NGS

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery