Présentation

Precision DNA Synthesis Paired with Multi-Parameter Optimization

The antibody optimization process requires designing and testing many combinations of antibody variants to narrow in on a developable, functional, optimal candidate.

Applying our precision DNA synthesis to our Twist Antibody Optimization (TAO) toolbox, we can create customized phage display libraries that humanize and enhance your leads for improved affinity, developability, selectivity, and more. Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will transform your sequence into a personalized phage display library.

 

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Precision DNA Synthesis Paired with Multi-Parameter Optimization

The antibody optimization process requires designing and testing many combinations of antibody variants to narrow in on a developable, functional, optimal candidate.

Applying our precision DNA synthesis to our Twist Antibody Optimization (TAO) toolbox, we can create customized phage display libraries that humanize and enhance your leads for improved affinity, developability, selectivity, and more. Simply input your murine, chimeric, humanized, or fully human antibody sequence, and our algorithm will transform your sequence into a personalized phage display library.

 

graphique

 

 

AVANTAGES

More Efficient Antibody Optimization

TAO uses a wide sequence space of 108 of natural human antibody sequences, creating an optimization library that precisely matches the human repertoire.

Concurrent Optimization Around Multiple Parameters

By precisely defining the sequence space explored, we can explicitly remove isomerization, cleavage, deamidation, glycosylation, and dipeptide liabilities. Simultaneously, Twist can also focus on humanizing leads, improving biophysical properties, and enhancing affinity and selectivity.

Élaboré avec une synthèse d'ADN de précision

Our rapid, scalable DNA synthesis platform enables quick generation of defined synthetic libraries, focused on the most relevant sequence space. We convert your lead antibody to the closest germline sequence and comprehensively explore the mutational space with unprecedented efficiency.

Assistance de bout en bout pour le développement d'anticorps

Our DNA synthesis capabilities enable us to offer high-throughput conversion from scFv, Fab, or VHH formats to full-length IgG. Our team of antibody experts leverages their collective 50 years of experience to streamline development, with biophysical, and functional screening of any optimized leads.

Assistance de bout en bout pour le développement d'anticorps

end to tend

More Efficient Antibody Optimization

TAO uses a wide sequence space of 108 of natural human antibody sequences, creating an optimization library that precisely matches the human repertoire.

Concurrent Optimization Around Multiple Parameters

By precisely defining the sequence space explored, we can explicitly remove isomerization, cleavage, deamidation, glycosylation, and dipeptide liabilities. Simultaneously, Twist can also focus on humanizing leads, improving biophysical properties, and enhancing affinity and selectivity.

Élaboré avec une synthèse d'ADN de précision

Our rapid, scalable DNA synthesis platform enables quick generation of defined synthetic libraries, focused on the most relevant sequence space. We convert your lead antibody to the closest germline sequence and comprehensively explore the mutational space with unprecedented efficiency.

Assistance de bout en bout pour le développement d'anticorps

Our DNA synthesis capabilities enable us to offer high-throughput conversion from scFv, Fab, or VHH formats to full-length IgG. Our team of antibody experts leverages their collective 50 years of experience to streamline development, with biophysical, and functional screening of any optimized leads.

Assistance de bout en bout pour le développement d'anticorps

end to tend

RESSOURCES TECHNIQUES

Ressources techniques

TAO : optimisation d’anticorps Twist pour un anticorps anti-PD-1

Case StudiesBiopharma

Download the case studies

Twist Antibody Optimization Platform

Fiche de produitBiopharma

Download the service sheet

Ressources techniques

TAO : optimisation d’anticorps Twist pour un anticorps anti-PD-1

Case StudiesBiopharma

Download the case studies

Twist Antibody Optimization Platform

Fiche de produitBiopharma

Download the service sheet

Contactez-nous

Nos experts en anticorps se tiennent à votre disposition et aimeraient en savoir plus sur vos besoins en matière de recherche. Les cibles difficiles sont les bienvenues !

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