Precision Targeting for Confident Results

Uniform coverage and precise variant detection where it matters most.

Confidence When Every Read Counts

Confidence in every read separates signal from noise. Missed exons, biased fragments, or uneven coverage can hide critical variants, transcripts, or methylation sites. Twist delivers integrated fragmentation-to-enrichment solutions that maintain consistency and clarity across your entire sequencing workflow

Focuses sequencing on key regions for meaningful depth.
Cuts excess sequencing and analysis to lower cost and data load.
Improves sensitivity for low allele frequency variants.
Supports tailored panels for specific pathways or research goals.

Why Target with Twist

Target enrichment workflows with Twist deliver scalable, low bias, and highly uniform coverage across large and complex genomic regions; enabling broader discovery, higher sensitivity, and greater flexibility than amplicon or array based methods.

	Twist Target Enrichment NGS Method	Amplicon Sequencing NGS Method	Array-Based Analysis NGS Method
Design Method	Fully customizable panels	Fixed amplicons; redesign requires new primers	Fixed content; no new targets
Performance traits	Uniform coverage, even in GC-rich regions	Uneven due to PCR bias	Limited to preset markers
Variant classes	Detects SNVs, indels, CNVs, fusions, isoforms	Good for small SNVs; poor for complex variants	Only known variants
Throughput / Format	Scales from small to million-probe panels	Hard to scale large panels	Must buy new arrays for expansion
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How it works

Target Enrichment Sequencing Workflow

Target enrichment selectively captures the regions that matter; genes, exons, splice sites, or CpG islands; focusing sequencing power for deeper coverage, fewer wasted reads, and faster results.

Why choose us

Complete your Target

Enrichment Workflow

Library Prep that Powers Exceptional Target Enrichment

Twist’s library prep uses engineered enzymes and optimized chemistry to generate consistent libraries with optimal inserts, strong uniformity, and high on target performance.

Hybridization Chemistry Engineered for High Fidelity Capture

Twist’s target enrichment optimizes hybridization to deliver balanced ligation, uniform inserts, reduced off target noise, and stronger sensitivity.

Fixed and Custom Panels Engineered for Precise, Reliable Target Enrichment

Twist’s fixed and custom panels use optimized probe designs and high uniformity capture to deliver consistent coverage, balanced performance, and strong sensitivity.