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Library Preparation Solutions

Prep sequencer-ready libraries for DNA, RNA, or methylation profiling using Twist's expansive suite of library prep kits. From abundant genomic DNA to low-input FFPE samples, we've got tools to help.

Why choose us

Prepare For Greatness

Low-input, High Return

Twist kits are designed to help you prepare quality libraries from some of the most challenging sample types, be it cfDNA or FFPE.

Flexible

Twist's suite of kits can be tailored to your needs, supporting enzymatic or mechanical fragmentation, targeted or whole genome sequencing, and high- or low-input samples.

Scalable

Hands-free normalization and high-quality adaptors enable high performance library prep at any scale.

Compares

Overview of workflow application options

Based on your application needs, create sequencing ready libraries in as little as two hours.

What we offer

Our Library Preparation Solutions

Featured Products

PCR Free LP Kit

Kits

RNA Library Prep Kit

Library Preparation Solutions | Kits

Comprehensive RNA-seq library prep kit generating high-quality libraries from low-input or FFPE samples in under 5 hours, with optional depletion and enrichment compatibility.

Mechanical Fragmentation Library Prep Kit

Library Preparation Solutions | Kits

Rapid 2.5-hour NGS library prep kit for mechanically sheared DNA, providing reliable, high-quality sequencing results across diverse sample types and input ranges.

Enzymatic Fragmentation 2.0 Library Prep Kit

Library Preparation Solutions | Kits

High-fidelity library prep kit for low-input or FFPE DNA, combining enzymatic fragmentation and single-tube workflow for accurate, efficient, and automation-ready NGS results.

FlexPrep UHT Library Prep Kit

Library Preparation Solutions | Kits

Ultra-high throughput library prep kit with built-in normalization and early barcoding, enabling 12-sample pooling for faster, cost-efficient population and agrigenomic studies.

96-Plex Library Prep Kit

Library Preparation Solutions | Kits

High-throughput 96-plex library prep kit for cost-efficient whole genome sequencing, enabling up to 960 samples with full-length Illumina-compatible adapters from minimal DNA input.

Methylation Detection System

Library Preparation Solutions | Kits

Comprehensive enzymatic methylation detection system identifying 5mC and 5hmC with superior sensitivity, reduced off-target capture, and compatibility with Twist Methylome or custom panels.

Adapters

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Universal Adapter System

Library Preparation Solutions | Kits

TruSeq-compatible 10 bp adapters for all 'T-A' overhang workflows, preventing dimer formation and improving yield for efficient, high-quality NGS library preparation.

Methylated UMI Adapter System

Library Preparation Solutions | Kits

TruSeq-compatible methylated UMI adapters optimize cfDNA methylation studies by reducing false duplicates, preserving fragment integrity, and enhancing coverage, accuracy, and reproducibility in EM-seq workflows.

UMI Adapter System

Library Preparation Solutions | Kits

TruSeq-compatible UMI adapter system enabling accurate low-frequency variant detection from cfDNA and gDNA by reducing PCR errors and enhancing sequencing sensitivity.

Not sure which solution fits your workflow?

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