Exploration of Natural Product Biosynthetic Enzymes and Chemoenzymatic Synthesis of Complex Molecules

Presented by

Kenichi Matsuda

Associate Professor, Hokkaido University, Japan

Covered in this Webinar

Metabolic pathways represent a vast, underutilized reservoir of enzymes capable of facilitating intricate molecular transformations.

PBP-type thioesterases (TEs) from actinomycetes are powerful tools for efficient chemoenzymatic peptide synthesis.

Reductions in waste generation can be achieved through bioengineering and synthetic biology.

The application of enzyme catalysts, which enable selective molecular transformations under mild conditions, is rapidly expanding across pharmaceutical R&D and manufacturing. However, the vast majority of natural enzymes remain unexplored.

In this seminar, Dr. Matsuda will introduce families of useful enzymes discovered through natural product biosynthetic pathways. In particular, Dr. Matsuda will present recent efforts in the chemo-enzymatic synthesis of cyclic peptides using a novel peptide cyclase derived from actinobacteria: a PBP-type thioesterase.

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Exploration of Natural Product Biosynthetic Enzymes and Chemoenzymatic Synthesis of Complex Molecules

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