Engineering Compact Base Editors: AlphaFold-Guided Design Meets Directed Evolution

Presented by

Jungjoon Kempthorne Lee Ph.D.

National University of Singapore (NUS), Singapore

Covered in this Webinar

Discover how AlphaFold3-guided alanine scanning can identify a single key residue that unlocks a ten-fold improvement in base editing activity

Learn how Trinity-Screen unifies activity, indel reduction, and cytotoxicity selection into one single E. coli workflow

Understand how precise oligo synthesis from Twist Bioscience complements AI-generated models to benchmark base editors with confidence

Join us for an exciting webinar where we dive into a new integrated framework for developing next-generation, compact base editors.

In this webinar, Asst Prof Jungjoon Kempthorne Lee will discuss how his team transformed SsdAtox - a small but inefficient deaminase toxin - into a compact base editor variant that demonstrates substantially improved performance relative to BE4max benchmarks.

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Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Antibodies

Engineering Compact Base Editors: AlphaFold-Guided Design Meets Directed Evolution

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