Critical Reagents and Tool Antibodies

Your trusted partner to deliver assay-ready anti-idiotypic antibody reagents and antigen design and production

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Overview
Anti-Ids
Custom Antigen

What is Critical Reagents and Tool Antibodies?

Across antibody discovery and development spectrum, you need high-quality proteins, cell lines, DNA, and other critical reagents to confidently strategize your immunization, screening, functional characterization, and optimization protocols. This is critical to the selection of potent, safe, and efficacious biotherapeutics. Generating these reagents and tool antibodies such as Anti-Ids for your development campaigns with highly qualified and robust workflows and starts with a trusted, experienced, and attentive partner.

Anti-Idiotypic Antibody Discovery Services

At Twist Biopharma Solutions, we approach your drug development endeavors with the end goal in mind. Anti-idiotypic (anti-ids) antibodies play a pivotal role in the preclinical journey by serving as valuable reagents for quality control, ensuring the specificity and efficacy of therapeutic antibodies. These antibody tools are essential for assessing the immunogenicity and safety profiles of biologics, aiding in the detection of unwanted immune responses and ultimately accelerating the development of novel therapies with improved efficacy and safety profiles.

Superior Antibody Diversity

Twist's platform produces a diverse panel of target specific anti-idiotypic antibodies using our proprietary hyperimmune DiversimAb™ Mouse.

Advanced Affinity and Specificity Screenings

Industry-leading, function-forward screening packages offer anti-ids stringently screened for binding affinity in the presence of human serum using both ELISA and BLI to deliver ideal antibodies ready for validation assays.

Rapid, Predictable Project Timelines

Twist devises an industry-leading anti-idiotypic antibody discovery platform that offers either single B-cell screening or integrated hybridoma workflows to de-risk projects and improve the predictability of timelines.

Proven Expertise and 97% Success Rate

250+ successful anti-idiotypic antibody programs.

97% success rate based on project requirements.

Success in different therapeutic modalities, including monoclonal antibodies, bispecifics, ADCs, and cell therapy products.

What are Anti-Idiotypic Antibodies?

Anti-idiotypic antibodies are antibodies that bind to the idiotype of another antibody or biologic, typically an antibody drug. Anti-ids are important downstream reagents for specific drug development assays (e.g. PK and ADA), as well as many other applications such as diagnostic assays and biomarker discovery and evaluation.

There are different ways an anti-idiotypic antibody can interact with an antibody via different regions. The key success factor for the development is the understanding of the intended applications and design of proper screening cascades for the selection of ideal anti-idiotypic antibodies. Twist Biopharma Solutions develops industry-leading technologies and workflows that will drastically enhance the success of anti-idiotypic antibody discovery campaigns.

Anti-Idiotypic Antibody Workflows, Customized for your Development Program

Custom Antigen Production and Design

The quality of your antigen is critical to the success of every antibody discovery project. At Twist Biopharma Solutions, we’ve built our antigen production capabilities to offer a reliable source of high-quality reagents and give our clients flexibility without sacrificing a streamlined workflow.

Our molecular biology team has years of experience generating reagents for antibody discovery campaigns. We have also optimized our immunization techniques to generate robust immune responses to difficult target classes.

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Gene-to-Protein Recombinant Antigen Development

Using our industry-leading team of cell culture, purification, and analytical experts, we generate high-purity research-grade proteins or antibodies delivered on time to meet your exacting expectations. Equipped with state-of-the-art and high-throughput cell culture and purification systems, we produce a wide array of proteins to support your research goals.

Cell Line Generation

We have incorporated transient cell line generation to meet your needs and continue to provide robust cell-based antibody discovery services. Our transient approach allows for quick and efficient success in our discovery campaigns.

Peptide and Small Molecule Antigens

Our immunization expertise enables us to make highly specific, high-affinity antibodies against peptides and small molecules that may not be immunogenic in other in vivo systems.

Off-the-Shelf Antigens

Our commercial collaboration with Acro Biosystems allows you to access thousands of recombinant proteins on expedited timelines. Having a high-quality, trustworthy provider allows projects to start faster.

What Scientists Have to Say

“

I can always trust that I’ll have no surprises when I’m working with the Twist Biopharma Solutions team, and that’s why I continue to come back. I’ve outsourced dozens of anti-id programs during my career and there have been too many times where simple oversights have cost me 6+ months in assay development. For these high-impact translational programs, it’s critical we get it right the first time.”

Director of Translational Development

Biopharma

“

At Promega, we struggled to acquire a high-affinity, high-specificity antibody against one target of interest. After failing with two previous vendors, we enlisted the help of Twist Biopharma Solutions and their DiversimAb approach, and we soon had a multitude of high-quality clones to choose from. We eventually chose a clone that far exceeded our expectations for performance. We were continually impressed by their high-quality analytical data, excellent communication, and overall collaborative spirit.”

Promega Corporation

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