These Biopharma Services Terms and Conditions (“Agreement”) govern the performance of certain services by Twist Bioscience Corporation, and/or AbX Biologics DBA Abveris, Inc., a division of Twist Bioscience Corporation, having its principal place of business at 1250 Hancock Street, Suite 210N, Quincy, MA 02169, USA (individually, and collectively, referred to in this Agreement as “us”, “we”, or “our” or “Twist”) for you (the “Company”), all as described under and subject to the terms and conditions of this Agreement and each applicable Research Plan. Company and Twist may be referred to herein individually as a “Party” and collectively as the “Parties.”

1. 服务
   1. Research Plans. During the term of this Agreement, Company and Twist may enter into a written document setting forth the respective responsibilities of Twist and Company (if any) for the purpose of engaging in the corresponding research plan (each, a “Research Plan”). A sample Research Plan Template is attached hereto as Exhibit A. In the event that Company and Twist reach agreement with respect to a particular Research Plan, such Research Plan together with this Agreement shall collectively constitute the entire agreement for the specific Research Plan. No Research Plan or any modifications thereto, shall be attached to or made a part of this Agreement without first being executed by the Parties hereto in writing which specifically references this Agreement. To the extent any terms set forth in the Research Plan conflict with the terms of this Agreement, the terms of this Agreement shall control unless otherwise expressly agreed by the Parties in such Research Plan. Company agrees that Twist may exercise any right or satisfy any obligation under the Agreement or any Research Plan via its affiliates. Twist shall cause its affiliates, including the issuance of Research Plans in the sole name of such affiliate, to comply with the terms and conditions of this Agreement and/or any applicable Research Plan. Twist affiliates may assign any Research Plans issued hereunder to Twist without Company’s consent.
   2. Deliverables. Twist agrees to use commercially reasonable efforts to provide and perform the services set forth in a Research Plan in accordance with the terms and conditions of this Agreement and such Research Plan. Such services may include supplying certain deliverables specified in a Research Plan (the “Deliverable(s)”). Twist may cancel a Research Plan if Twist determines (in its reasonable discretion) a need to do so for biosecurity, biosafety, intellectual property infringement, confidentiality breaches, export restrictions and/or feasibility reasons. Any cancellation of a Research Plan as described above shall be without penalty or liability to Twist (provided that any prepaid amounts for such Research Plan shall be refunded to Company by Twist, or if Company so requests, credited toward future Research Plans under this Agreement; except where such cancellation results from intellectual property infringement or confidentiality breaches by Company). Notwithstanding anything to the contrary herein, nothing in the Agreement shall limit or restrict Twist’s right and ability at all times to provide products and services to third parties which are similar or identical to the Deliverables made, or services provided, under such Research Plan or this Agreement, provided that no Company Materials or Company Confidential Information (each as defined below) are used in providing such services to third parties.
   3. 发货和交付条款。 Twist will use commercially reasonable efforts to generate and supply the Deliverables. All Deliverables will be shipped Ex Works (Incoterms 2020) from Twist’s facility to the delivery address specified in the Research Plan. Except as otherwise stated in the Research Plan, Twist may ship all Deliverables using the means and carrier of its choice. Twist does not clear Deliverables for import into the country specified in the delivery address, if outside the U.S., which is Company’s sole responsibility. Deliverables are deemed shipped and delivered to Company when tendered to the applicable commercial carrier at Twist’s facility. At this point, title to the Deliverables passes to Company and Company becomes responsible for risk of loss and damage.
   4. Research Plan Variations. Company may request modifications to a Research Plan prior to or during the Research Plan; and, as warranted, Twist will submit to Company an updated proposal regarding the Fees for such modification. The acceptance of such modification shall be made in writing by both Parties which shall be a precondition to Twist’s obligation hereunder to use commercially reasonable efforts to perform services in accordance with the modified Research Plan.
   5. Subcontracting. Twist may assign, delegate or subcontract any of its obligations under this Agreement without the prior written approval of Company; provided that Twist shall remain responsible and liable for its obligations under this Agreement, including the performance of all of its subcontractors under this Agreement.
2. COMPANY MATERIALS, RESTRICTIONS AND RESPONSIBILITIES
   1. Company Materials. To the extent required under a Research Plan, Company shall provide (or has provided) to Twist sufficient amounts of materials and accurate and up to date information, in each case, in accordance with applicable law and regulation, to be used by Twist to perform under this Agreement (collectively, “Company Materials”) at its sole expense in a prompt and timely manner. Company Materials shall also include materials procured by Twist on behalf of Company. Company shall be responsible and liable for such Company Material and Twist’s use and exploitation of such Company Materials. Company shall retain all right, title, and interest in and to the Company Materials (subject to the rights and licenses expressly provided for in this Agreement).
   2. Twist Use of Company Materials. To the extent Company Materials are provided pursuant to a given Research Plan, Company hereby grants Twist its affiliates and/or subcontractors (as applicable) a non-exclusive license to use, develop and transfer the Company Materials to perform the applicable Research Plan. Twist shall have no obligation to return any unused Company Materials nor shall Twist have any liability for any damage to or destruction of any Company Materials. Company has read and hereby acknowledges Twist’s published Privacy Policy available at https://www.twistbioscience.com/privacy-policy.
   3. Use of Deliverables. Company acknowledges and agrees that all Deliverables provided by Twist are intended for research use only and are not intended for use in any clinical or diagnostic procedures. Company shall be solely responsible and liable for any use of the Deliverables, including any usage that requires or for obtaining any approval, validation, testing, clearance, required authorizations, licensing, consents, or exemptions, and labeling requirements by the FDA or any other applicable governmental agency or by applicable law and regulations. Company shall use all Deliverables in accordance with applicable laws, rules, regulations and governmental policies and in accordance with the terms and conditions of this Agreement. No Deliverable or service under the Research Plan has been approved, cleared, authorized or licensed by the FDA or any other applicable governmental agency, within or outside the United States, for any use. . 
3. 购买价格；费用和付款期限

Company shall pay Twist the purchase price, fees and other amounts (if any) specified in each Research Plan (collectively, “Fees”) in accordance with the terms of the applicable Research Plan. Pricing does not include shipping, handling, freight, insurance, taxes and customs, which Company is responsible for paying and which, as applicable, Twist may add to Company’s invoice. Only the Fees in a Research Plan are valid and Twist shall not be bound or subject to any other pricing, regardless of where stated or published. Company shall pay the Fees to Twist in accordance with the timelines set forth in an applicable Research Plan. Except to the extent expressly provided otherwise in this Agreement or an applicable Research Plan, all Fees are non-cancelable, non-creditable and non-refundable and are due within thirty (30) days of the date of Twist’s invoice. Without limiting any other rights or remedies of Twist, failure of Company to pay any Fees when due shall entitle Twist to suspend completion of any pending Research Plans unless and until such Fees are paid.

4. 知识产权
   1. Ownership
      1. Company Ownership. Subject to Section 4.1.2 below, Twist agrees that all Deliverables shall, as between the Parties, be the sole and exclusive property of Company. Twist neither represents nor warrants that any intellectual property rights, including any Patent Rights, in Deliverables are available and Company shall be solely responsible for obtaining any authorizations, approvals, permits or licenses required from any governmental authority or third party in connection with any use of such Deliverables. Except for Twist Intellectual Property (as defined below in Section 4.1.2), as between the Parties, Twist agrees to assign and hereby assigns all right, title and interest in and to such Deliverables to Company, and to execute any documents Company may reasonably require relating thereto.
      2. Twist Ownership. Twist shall retain all right, title, and interest in and to Twist’s intellectual property used or practiced in connection with its Deliverable, product, gene or DNA synthesis, assembly and manufacturing, including, without limitation, any suggestions, improvements or modifications to each of the foregoing and any other inventions generated in performance of this Research Plan that are not assigned to Company in Section 4.1.1, in each case whether or not developed, created, derived or improved in connection with Twist’s performance under this Agreement and the Research Plan, and/or all of Twist’s technology, Know-How, Patent Rights and intellectual property (collectively, “Twist Intellectual Property”), whether or not developed, created, derived or improved by either Party (alone or jointly with others), and Company agrees to assign and hereby assigns all of its rights, title and interest in and to the Twist Intellectual Property to Twist.
      3. No Rights or Licenses. No rights or licenses in, to or under either Party’s intellectual property are granted or provided hereunder, by implication, estoppel or otherwise, except to the extent expressly provided for in this Research Plan.
   2. License to Company. In the event Twist incorporates any Twist Intellectual Property into any Deliverables shipped to Company and duly paid for by Company, Twist will grant and does hereby grant to Company a perpetual, non-transferable, non-sublicensable, non-exclusive, fully paid-up worldwide license to use such Twist Intellectual Property incorporated into such Deliverables solely as incorporated into and solely as necessary to use such Deliverables. Company is solely responsible for determining if there are any restrictions on use of Deliverables resulting from any third-party patents or other proprietary rights.
5. 保密条款

“Confidential Information” means any information disclosed by or on behalf of either Party or its representatives (the “Disclosing Party”) to the other Party (the “Receiving Party”) pursuant to this Agreement that is (a) marked “Confidential” or “Proprietary” or (b) otherwise reasonably expected to be treated in a confidential manner under the circumstances of disclosure or by the nature of the information itself. “Confidential Information” does not include: (i) any information that is publicly available or becomes publicly available through no action or inaction of the Receiving Party; (ii) is in the rightful possession of the Receiving Party without confidentiality obligations at the time of disclosure by the Disclosing Party to the Receiving Party as shown by the Receiving Party’s then contemporaneous written files and records kept in the ordinary course of business; or (iii) is obtained by the Receiving Party from a third party without an accompanying duty of confidentiality and without a breach of such third party’s obligations of confidentiality. The Receiving Party shall: (A) use the Confidential Information of the Disclosing Party solely to exercise its rights and fulfill its obligations under these Agreement and the applicable Research Plan; (B) shall not disclose Disclosing Party’s Confidential Information to any third parties other than its own employees, Twist’s subcontractors or agents on a need to know basis who are subject to written obligations of confidentiality and non-use that are at least as protective of Disclosing Party’s Confidential Information as this Agreement, except with the Disclosing Party’s express written consent; and (C) at least take the precautions to protect the secrecy of and avoid disclosure and unauthorized use of the Disclosing Party’s Confidential Information that the Receiving Party employs to protect its own confidential information of a similar nature, but in no event less than reasonable care. All Company Materials shall be Confidential Information of Company. Twist Intellectual Property shall be the Confidential Information of Twist. This Agreement and any other aspects of a Research Plan shall be the Confidential Information of both Parties. If the receiving Party becomes legally compelled to disclose any Confidential Information pursuant to applicable law, regulation or SEC reporting obligations, the Receiving Party will provide the Disclosing Party with prompt written notice, if legally permissible, and disclose only that portion that is legally required to be disclosed; provided that any Confidential Information so disclosed shall maintain its confidentiality protection for all other purposes. Subject to Section 2.2, Upon termination or expiration of the Agreement, or upon written request of the Disclosing Party, the Receiving Party shall promptly return or destroy all documents, notes and other tangible materials representing the Disclosing Party’s Confidential Information and all copies thereof (excluding any Confidential Information that is subject to a surviving license granted to the Receiving Party hereunder); provided, however, that the Receiving Party may retain a copy of such Confidential Information under conditions of confidentiality solely for (i) legal archival purposes, and (ii) compliance with the surviving provisions of this Agreement and/or applicable laws and regulations, and (iii) for any backup that cannot be deleted by IT. The Parties expressly acknowledge and agree that any breach or threatened breach of this Section 5 by the Receiving Party may cause immediate and irreparable harm to the Disclosing Party that may not be adequately compensated by damages. Each Party therefore agrees that in the event of such breach or threatened breach by the Receiving Party, and in addition to any remedies available at law, the Disclosing Party shall have the right to seek equitable and injunctive relief, without bond, in connection with such a breach or threatened breach. 

6. 保证限制和免责声明

THE DELIVERABLES ARE PROVIDED “AS IS” WITHOUT ANY WARRANTY, REPRESENTATION OR GUARANTEE OF ANY KIND AND TWIST MAKES NO, AND HEREBY DISCLAIMS ALL, REPRESENTATIONS AND WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, WITH RESPECT TO THE DELIVERABLES OR ANY OTHER SUBJECT MATTER OF THIS AGREEMENT, INCLUDING, WITHOUT LIMITATION, THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT AS WELL AS WARRANTIES REGARDING SECURITY, RESULTS OBTAINED THROUGH THE USE OF ANY DELIVERABLES AND ANY WARRANTY ARISING FROM A STATUTE OR OTHERWISE IN LAW OR FROM A COURSE OF PERFORMANCE, DEALING OR USAGE OF TRADE.

7. 赔偿；责任限制
   1. Twist 的责任。 Twist shall indemnify, defend and hold harmless Company and its affiliates and their respective directors, officers, employees, and agents (the “Company Indemnitees”) from and against any and all costs, expenses, liabilities, damages and losses (including reasonable legal expenses and attorneys’ fees) arising out of any third party suits, claims, actions, or proceedings (collectively, “Claims”) brought against any Company Indemnitees to the extent resulting from or caused by:  the gross negligence, recklessness or willful misconduct of Twist Indemnitees; except in each case to the extent that a Claim arises out of or results from the gross negligence, recklessness or willful misconduct of any Company Indemnitee or Permitted Transferee.
   2. By Company. Company shall indemnify, defend and hold harmless Twist and its affiliates and each of its directors, officers, employees, and agents (the “Twist Indemnitees”) from and against any and all Claims brought against any Twist Indemnitees to the extent resulting from or caused by: (a) the gross negligence, recklessness or willful misconduct of any Company Indemnitee or Permitted Transferee; (b) the use or other exploitation of any Company Materials or Deliverable(s); or (c) the infringement or alleged infringement of any third party intellectual property rights arising from the use of any Company Materials or Deliverable(s); except in each case to the extent that a Claim arises out of or results from the gross negligence, recklessness or willful misconduct of any Twist Indemnitee.
   3. 赔偿条件和程序。 Each Party’s obligations in this Section 7 are conditioned on the indemnified Party: (a) providing prompt written notice to the indemnifying Party of any Claim; (b) permitting the indemnifying Party to assume full and exclusive control over the defense and settlement of such Claim, except that the indemnified Party may participate in the defense at its own expense using its own counsel; and (c) providing reasonable cooperation, information and assistance to the indemnifying Party, at the indemnifying Party’s reasonable expense, with respect to the defense and settlement of such Claim. Notwithstanding the foregoing, the indemnifying Party shall not enter into any settlement that admits the fault of the indemnified Party or otherwise materially adversely prejudices the indemnified Party without such indemnified Party’s prior written consent, such consent not to be unreasonably withheld, conditioned or delayed.
   4. 责任限制。 EXCEPT FOR A PARTY’S (I) BREACH OF SECTION 2.1 AND 2.3, (II) INDEMNIFICATION OBLIGATIONS UNDER SECTION 7, OR (III) GROSS NEGLIGENCE, INTENTIONAL MISCONDUCT, OR FRAUD, NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY HEREUNDER FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, PUNITIVE OR INDIRECT DAMAGES OF ANY KIND ARISING FROM OR IN CONNECTION WITH THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES AND REGARDLESS OF THE THEORY OF LIABILITY. EXCEPT FOR ANY LIABILITY THAT CANNOT BE EXCLUDED BY LAW, TWIST SHALL NOT BE LIABLE FOR ANY DAMAGES OR OTHER AMOUNTS ARISING OUT OF OR IN CONNECTION WITH THIS AGREEMENT IN EXCESS OF THE LESSER OF (I) THE FEES PAID BY COMPANY TO TWIST HEREUNDER DURING THE TWELVE (12) MONTHS PRECEDING THE CLAIM UNDER WHICH SUCH LIABILITY AROSE OR (II) ONE (1) MILLION ($1,000,000) USD DOLLARS.
8. 期限和终止

Either Party may terminate this Agreement at any time with or without cause for its convenience, effective upon ninety (90) days prior written notice to the other Party. Unless Twist terminates this Agreement for cause (including Company’s failure to pay Fees), any Research Plans not completed before the effective date of expiration or termination of this Agreement shall survive expiration or termination of this Agreement until completed. Twist shall be entitled to receive and retain and Company shall pay to Twist all Fees, including but not limited to a percentage of the contracted amounts corresponding to the value of the work performed plus any uninvoiced amounts, reasonably incurred expenses and materials, and non-cancelable costs, due for any Research Plans in effect at the effective date of termination of this Agreement. Sections 1.3, 2.3, and 3-10 shall survive any termination of this Agreement. 

9. 出口管制

Company may not, directly or indirectly, sell, export, re-export, transfer, divert, or otherwise dispose of any Deliverables or information (including products derived from or based on Deliverables or information) to any destination, entity, person or end user in violation of any applicable export control laws or regulations. Company shall provide assistance and information as needed for Twist to meet its trade compliance obligations arising from this Agreement.

10. 总则

Each Party represents and warrants that: (a) it is a corporation duly organized, validly existing, and in good standing under the laws of its jurisdiction; (b) it has the requisite power and authority to execute, deliver, and perform in accordance with this Agreement; (c) the execution, delivery and performance of this Agreement do not and shall not conflict with or result in a breach of any provision of any agreement to which it is a party, or violate any applicable laws. This Agreement is governed by the laws of the State of California without reference to any conflict of laws principles. Any dispute, controversy or claim arising from this Agreement which cannot be resolved through direct negotiations shall be resolved by binding arbitration in accordance with and subject to the then applicable rules (“Rules”) of the Judicial Arbitration and Mediation Services (“JAMS”) in the city of San Francisco, California, USA. Judgment upon the award rendered in any such arbitration may be entered in any court of competent jurisdiction, or application may be made to such court for a judicial acceptance of the award and an enforcement, as the law of such jurisdiction may require or allow. Notwithstanding the foregoing, nothing in this section shall prevent either Party from applying to a court of competent jurisdiction for equitable or injunctive relief. This Agreement may not be assigned or otherwise transferred, in whole or in part, by operation of law or otherwise, by either Party without the other Party’s express prior written consent subject to Section 1.1; provided, however, that either Party may assign this Agreement without such consent to its successor in interest in connection with any merger, consolidation, reorganization or sale of such Party or all or substantially all of its assets. No rule of strict construction or construing of ambiguities against a drafting Party will be applied in the interpretation or construction of this Agreement. Each Party must deliver all notices, consents, and approvals required or permitted under this Agreement in writing to the other Party at the address specified in the Research Plan or Agreement. This Agreement, including any Research Plan, is the final, complete, and exclusive agreement of the Parties and supersedes all prior or contemporaneous communications and understandings, oral or written, between the Parties with respect to the subject matter hereof. No conflicting terms on invoices or other documentation issued between the Parties with respect to a Research Plan shall apply. No modification of or amendment to this Agreement will be effective unless in writing and signed by both Parties. Except as otherwise set forth in this Agreement, Company shall not use Twist’s logos or trade names for publicity, marketing, or any other external communications without Twist’s prior written consent. This Agreement may be executed in counterparts, each of which shall be an original, and all of which shall constitute together but one and the same document.

11. PUBLICITY

The Parties may make subsequent public reference to or disclosure of the contents of any mutually agreed upon and published press release, including use of the company name and/or logo of the other Party (subject to any provided brand guidelines) to generally publicize the existence of this Agreement between the Parties. Subject to the foregoing, each Party agrees not to issue any press release or other public statement, whether oral or written, disclosing the terms hereof or any activities under a Research Plan hereunder without the prior written consent of the other Party (such consent not to be unreasonably withheld, conditioned or delayed), provided however, that neither Party will be prevented from complying with any duty of disclosure it may have pursuant to applicable laws or pursuant to the rules of any recognized stock exchange or quotation system, subject to that Party notifying the other Party of such duty and limiting such disclosure as reasonably requested by the other Party (and giving the other Party sufficient time to review and comment on any proposed disclosure).

2022 年 3 月 8 日