Over the past decade, DNA sequencing has exploded, generating vast genomic datasets with surprisingly little functional insight into what most variants actually do. Codebreaker Labs’ high-throughput Causal Genomics platform fills this critical gap by directly testing variant effects through large-scale saturation mutagenesis, precise CRISPR editing, and single-cell analysis. By producing detailed, experimentally grounded variant effect maps across both common and rare variants, this approach unlocks powerful new opportunities in drug target discovery, biomarker validation, clinical study design, and AI model training.