Custom Antigen Design and Production

High-Quality Antibodies Start with High-Quality Antigens

Antigen Production Capabilities
BENEFITS

Start Your Discovery Campaign on the Right Foot

The quality of an antigen is critical to the success of every in vivo antibody discovery project. We built our antigen production capabilities to offer a reliable source of high-quality reagents and give our partners flexibility without sacrificing a streamlined workflow.

Twist’s Molecular Biology team has years of experience generating reagents for antibody discovery campaigns. We have optimized and proprietary techniques that generate robust immune responses for difficult target classes. Additionally, we can leverage our proprietary DiversimAb™ platform to induce immune responses against poorly immunogenic targets and improve antibody discovery timelines and success rates.

Immunization Expertise for any Antigen

Access Difficult-to-Express Antigens

Twist utilizes proprietary immunization vectors to directly express target antigens in mice, facilitating antibody discovery for challenging targets such as GPCRs and multi-spanning membrane proteins, and saving on antigen production costs and time. We can also leverage cell-based and subtractive immunization to enrich responses to cell-surface antigens.

Guidance from Antigen and Immunization Experts

The benefits of working with Twist include an experienced protein sciences team that reviews antigens and recommends critical sequence modifications before expression, optimized systems for rapid, ultra-high-yield protein production, high-level expression with appropriate post-translational modifications, and integrated antibody discovery capabilities.

Quick and Efficient Cell Line Generation

Our transient cell line generation approach allows our partners to quickly and efficiently succeed in their mAb discovery campaigns.

Rapidly Access 1000s of Off-the-Shelf Antigens

Thousands of recombinant protein antigens for popular targets are available on expedited timelines, so you can get your antibody discovery program going as quickly as possible.

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Antibody Discovery