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Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome(ポリコーム抑制複合体PRC1は、マウス胚性幹細胞のゲノムを空間的に制約する)
Schoenfelder S, Sugar R, Dimond A, Javierre B, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust EM, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S.
Nature Genetics. 2015 47 1179–1186
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C(高解像度キャプチャ型Hi-C法を用いたヒト細胞内の長距離プロモーター相互作用のマッピング)
Mifsud B, Tavares-Cadete F, Young AN, Sugar R, Schoenfelder S, Ferreira L, Wingett SW, Andrews S, Grey W, Ewels PA, Herman B, Happe S, Higgs A, LeProust EM, Follows GA, Fraser P, Luscombe NM, Osborne CS.
Nature Genetics. 47 (6) 598-606.
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements(プロモーターとその長距離相互作用要素をつなぐ多能性制御回路)
Schoenfelder S, Furlan-Magaril M, Mifsud B, Tavares-Cadete F, Sugar, R, Javierre B, Nagano T, Katsman Y, Sakthidevi M, Wingett SW, Dimitrova E, Dimond A, Edelman LB, Elderkin S, Tabbada K, Darbo E, Andrews S, Herman B, Higgs A, LeProust EM, Osborne CS, Mitchell JA, Luscombe NM, Fraser P.
Genome Res. 2015. 25: 582-597
Utilizing ethnic-specific differences in minor allele frequency to recategorize reported pathogenic deafness variants(民族に固有のマイナーアレル頻度の違いを利用した、従来報告されている難聴を引き起こす病的バリアントの再分類)
Shearer AE, Eppsteiner RW, Booth KT, Ephraim SS, Gurrola J, Simpson A, Black-Ziegelbein EA, Joshi S, Ravi H, Giuffre AC, Happe S, Hildebrand MS, Azaiez H, Bayazit YA, Erdal ME, Lopez-Escamez JA, Gazquez I, Tamayo ML, Gelvez NY, Leal GL, Jalas C, Ekstein J, Yang T, Usami S, Kahrizi K, Bazazzadegan N, Najmabadi H, Scheetz TE, Braun TA, Casavant TL, LeProust EM, Smith RJ.
The American Journal of Human Genetics. 95 4 445-453
Systematic Identification of Barriers to Human iPSC Generation
Qin H, Diaz A, Blouin L, Lebbink RJ, Patena W, Tanbun P, LeProust EM, McManus MT, Song JS, Ramalho-Santos M.
158 (2) 449–461
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MTa, Wiertz, EJa, and Lebbink RJa.
Nat Commun. (2014) 5: 3832.
Evidence for the biogenesis of more than 1,000 novel human microRNAs(1,000以上の新規ヒトマイクロRNAの生合成を示す証拠)
Friedländer MR, Lizano E, Houben AJS, Bezdan D, Báñez-Coronel M, Kudla G, Mateu-Huertas E, Kagerbauer B, González J, Chen KC, LeProust EM, Martí E, Estivill X.
Genome biology. 2014 15:R57
Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution(エクソン転写因子の結合がコドン選択を左右し、タンパク質の進化に影響を与える)
Stergachis AB, Haugen E, Shafer A, Fu W, Vernot B, Reynolds A, Raubitschek A, Ziegler S, LeProust EM, Akey JM, Stamatoyannopoulos JA.
Science. 2013 342(6164) 1367-1372
Advancing genetic testing for deafness with genomic technology(ゲノム技術を用いた難聴に対する遺伝子検査の進化)
Shearer AE, Black-Ziegelbein EA, Hildebrand MS, Eppsteiner RW, Ravi H, Joshi S, Guiffre AC, Sloan CM, Happe S, Howard SD, Novak B, Deluca AP, Taylor KR, Scheetz TE, Braun TA, Casavant TL, Kimberling WJ, Leproust EM, Smith RJ.
Journal of Medical Genetics. 2013 50(9) 627-34
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility(系統的な哺乳類の遺伝的相互作用マップを用いて、リシン感受性の基礎となる経路が明らかに)
Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS.
Cell. 2013 152(4) 909-22
Targeted genome enrichment for efficient purification of endosymbiont DNA from host DNA (宿主のDNAから内生生物のDNAを効率よく精製するためのターゲットゲノムエンリッチメント)
Geniez S, Foster JM, Kumar S, Moumen B, Leproust E, Hardy O, Guadalupe M, Thomas SJ, Boone B, Hendrickson C, Bouchon D, Grève P, Slatko BE.
Symbiosis. 2012 58 (1-3) 201-207
Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb(マウスMyHC IIbのモータードメインの突然変異による筋原線維性ミオパチー)
Kurapati R, McKenna C, Lindqvist J, Williams D, Simon M, LeProust E, Baker J, Cheeseman M, Carroll N, Denny P, Laval S, Lochmüller H, Ochala J, Blanco G.
Human Molecular Genetics. 2012 21(8) 1706-24
Autoantigen discovery with a synthetic human peptidome(合成ヒトペプチドームを用いた自己抗原の検出)
Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ.
Nature Biotechnology. 2011 29(6) 535-41
The GENCODE exome: sequencing the complete human exome(GENCODEエクソーム:ヒトの完全なエクソームのシーケンシング)
Coffey AJ, Kokocinski F, Calafato MS, Scott CE, Palta P, Drury E, Joyce CJ, Leproust EM, Harrow J, Hunt S, Lehesjoki AE, Turner DJ, Hubbard TJ, Palotie A.
European Journal Human Genetics. 2011 19(7) 827-31
Enrichment of sequencing targets from the human genome by solution hybridization(溶液を用いたハイブリダイゼーションによるヒトゲノムにおけるシーケンシング・ターゲットのエンリッチメント)
Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN,LeProust EM, Topol EJ, Harismendy O, Frazer KA.
Genome Biology. 2009 10(10) R116
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human(デジタル RNA アレルタイピングにより、ヒトの組織特異的およびアレル特異的な遺伝子発現を明らかに)
Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM.
Nature Methods. 2009 6(8) 613-8
Multiplex padlock targeted sequencing reveals human hypermutable CpG variations(マルチプレックス・パッドロック型標的配列解析により、ヒトの超突然変異型CpG変異が明らかに)
Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM.
Genome Research. 2009 19(9) 1606-15
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming(ターゲットバイサルファイトシーケンス解析により、核初期化に伴うDNAメチル化の変化が明らかに)
Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K.
Nature Biotechnology. 2009 27(4) 353-60
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing(超長鎖オリゴヌクレオチドを用いた超並列ターゲットシーケンシングのための溶液を用いたハイブリッドセレクション)
Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S, Jaffe DB, Lander ES, Nusbaum C.
Nature Biotechnology. 2009 27(2) 182-9
The DNA-encoded nucleosome organization of a eukaryotic genome(真核生物のゲノムにおける、DNAコード化されたヌクレオソームの構成 )
Kaplan N, Moore IK, Fondufe-Mittendorf Y, Gossett AJ, Tillo D, Field Y, LeProust EM, Hughes TR, Lieb JD, Widom J, Segal E.
Nature. 2009 458(7236) 362-6
Multiplex amplification of large sets of human exons(ヒトの広範なエクソンのマルチプレックス増幅)
Porreca GJ, Zhang K, Li JB, Xie B, Austin D, Vassallo SL, LeProust EM, Peck BJ, Emig CJ, Dahl F, Gao Y, Church GM, Shendure J.
Nature Methods. 2007 4(11) 931-6
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis(高度に並列化したin situオリゴヌクレオチド合成を用いた複雑な核酸ライブラリの作製)
Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N, Leproust E, Coffey EM, Burchard J, McCombie WR, Linsley P, Hannon GJ.
Nature Methods. 2004 1(3) 241-8
Effects of atmospheric ozone on microarray data quality(大気中のオゾンがマイクロアレイのデータ品質に与える影響)
Fare TL, Coffey EM, Dai H, He YD, Kessler DA, Kilian KA, Koch JE, LeProust E, Marton MJ, Meyer MR, Stoughton RB, Tokiwa GY, Wang Y.
Analytical Chemistry. 2003 75(17) 4672-5