The major histocompatibility complex (MHC) is one of the most polymorphic and clinically important regions of the genome. It is also one of the hardest to genotype. Most HLA typing still relies on PCR-based methods that call classical alleles without characterizing the sequence around them. In this webinar, Dr. Cornejo and colleagues present a different approach. They pair a hybrid capture panel with long-read sequencing (PacBio and ONT) to reconstruct full, phased gene sequences across the MHC. A single assay captures structural, protein-coding and regulatory variation, rather than returning only an allele name.