Access Hidden Epitopes with Ultralong HCDR3
The Twist Minotaur scFv Library is a new synthetic antibody library that grafts ultralong HCDR3 loops from bovine antibodies into a fully human antibody framework. These elongated HCDR3 loops protrude far from the antibody surface, enabling access to occluded epitopes within protein crevices, pores, and channels. This unique library can empower your therapeutic antibody discovery and development for any indication.
Be among the first to access the synthetic advantage for the discovery of antibodies against general and hard-to-drug targets like GPCRs, ion channels, and other membrane-bound proteins.
Produce scFv antibodies against challenging epitopes
Fully human antibody framework sequences
Proven, highly manufacturable framework with development liabilities removed
Two sub libraries of >109 diversity
Explore challenging epitopes with ultralong bovine HCDR3 loops
Ideal for targeting hard-to-reach epitopes
Ultralong HCDR3 loops up to 60 amino acids in length
Defined cysteine mutations replicate bovine antibody diversification
Synthetic library advantage
Panning to functional assays in 10-12 weeks without immunization
Focus on effective sequence space
Screen multiple targets simultaneously
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