Covaris DNA Fragmentation

A compatibility guide for Covaris fragmentation and Twist target enrichment

Many researchers depend on mechanical shearing using Covaris’ Adaptive Focused Acoustics (AFA) technology for library preparation. We provide here instructions for gDNA fragmentation with AFA technology for use with Twist’s target enrichment solution. This method has been optimized to yield high-quality gDNA fragments.

Covered in this Technical Note

Recommended materials

Instructions for fragmentation of gDNA and library preparation

Downstream experimental performance

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Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery

Covaris DNA Fragmentation

Highly Sensitive Methylation Detection Using Enzymatic Methyl-seq and Twist Target Enrichment

NEB Next Enzymatic Methyl-seq Library Preparation Protocol

Twist Targeted Methylation Sequencing Protocol