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Overview

Humanized Transgenic (HuTg) Mice

With proprietary mouse platforms comes a licensing process filled with legal fees, MTAs, royalty agreements, and restrictions. These hurdles can drain time and resources before R&D teams can begin in vivo discovery campaigns. Our humanized transgenic (HuTg) mouse platform is license-free, removing burdensome administrative barriers and supporting your path to discovery.

 

 

HuTg and DiversimAb – Better Together

Wild type, knockout and humanized in vivo platforms typically yield limited epitopic diversity, meaning fewer chances to uncover promising hits. To circumvent this, we offer to pair our HuTg mice with DiversimAb mice – a platform that generates a more diverse antibody repertoire – boosting epitope coverage, functional candidates and your chances of success.

 

 HUTG MICE OFFERED BY TWIST
DIVERSIMAB HYPERIMMUNE MICE
Other HuTg MICE
 
Licensing Required?NoNoYes 
Epitope Coverage and DiversityMedHighLow 
Affinity Rangesub nM+sub nM+sub nM+ 
Binders to high homology targets or epitopes?NoYesNo 
Rapid (3 week) immunization available?YesYesNo 
Performance with Beacon Single B Cell ScreeningGoodExcellentPoor 
Humanization Required?NoYesNo 
Risk of Developability LiabilitiesLowLowLow 
CostMedLowHigh 
Benefits

Humanized Mice: A Pathway to Preclinical Success

HuTg mice have been the origin for several commercially successful therapeutic antibodies. As in vivo antibody discovery evolves, humanized mouse platforms that generate robust immune responses and human antibody repertoires are key to reducing immunogenicity, accelerating lead optimization, and streamlining translation to the clinic.

 

 

Easing the Burden of Human Antibody Discovery

Our HuTg mice empowers your in-house antibody discovery efforts with faster timelines and at lower upfront costs, without the administrative red tape.

 

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License-Free Access
License-Free Access

Skip the paperwork and negotiations required by other humanized platforms. Our HuTg mice are ready to go, license-free.
High Titers, High Affinities
High Titers, High Affinities

HuTg mice are immunized using an optimized, rapid or extended protocol to produce high titers of antigen-specific B cells and affinities in the sub-nM range (and up).

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Fee-For-Service
Fee-For-Service

No licensing, tech transfer, milestone or royalty fees required. We offer predictable pricing that supports faster and more accessible discovery.
Flexible Discovery
Flexible Discovery

Maximize epitope coverage and de-risk your HuTg mice discovery campaign by integrating DiversimAb mice for expanded antibody diversity.

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Applications

Find Fully Human Hits in Weeks with Single B-Cell Screening

HuTg mice, like our DiversimAb platform, generate potent, highly-specific therapeutic and reagent antibody candidates. Both platforms are fully compatible with our Beacon-based single B-cell screening, enabling high-resolution, high-throughput hit identification and sequencing in a few weeks. Twist’s HuTg mouse workflow is particularly well suited for single B-cell screening, as they generate highly productive and active B cell populations, which is not typically seen with other humanized mouse platforms.

 

Hybridoma-Compatible Workflow

Twist also provides an end-to-end, adaptable hybridoma workflow for HuTg and DiversimAb mice that includes hybridoma generation, high-throughput screening, and sequencing to uncover promising hits.

Find Fully Human Hits in Weeks with Single B-Cell Screening

Resources

Learn more about humanized mice and Twist's in vivo discovery platforms

Product Sheet
Humanized Transgenic (HuTg) Mice for Monoclonal Antibody Discovery
Product Sheet
DiversimAb™ Mouse for Antibody Discovery